… of SARS-COV-2 M pro inhibitors. Like SARS-COV-1, SARS-COV-2 M pro inhibitors can be
… , and the mechanism of action of peptide inhibitors includes two steps. Peptidomimetics that …

… The structure of SARS-CoV-2 M pro in complex with N3 provides a model for identifying lead
inhibitors to target SARS-CoV-2 M pro using in silico screening. To achieve this, we docked …

… The cleavage site of Mpro is between a glutamine at the P1 site and a small residue at P1′…
for inhibitors of SARS-CoV-2 Mpro. We will focus on the SARS-CoV-2 Mpro inhibitors that …

… inhibitors. With the recent reporting of the X-ray crystal structure of the SARS-CoV-2 M pro ,
studies to discover M pro inhibitors … -molecule inhibitors targeting the SARS-CoV-2 M pro . …

… Here, we describe the design of 32 new SARS-CoV-2 M pro inhibitors, two of which show …
structures of SARS-CoV-2 M pro (11–13) and our cocrystal structures of SARS-CoV-2 M pro in …

… Thus, this review focuses on the structural features and function of 3CL pro and recent
advances in the discovery of SARS-CoV-2 3CL pro inhibitors, aiming to provide a SARS-…

… of an M pro inhibitor in a transgenic mouse model of SARS-CoV-2 infection (16). Given the
pivotal role of SARS-CoV-2 M pro in … challenges, SARS-CoV-2 M pro inhibition represents an …

… cysteine residue of Mpro for blocking … inhibitors of Mpro and PLpro significantly reduce
SARS-CoV-2, and can be used in combination for an enhanced antiviral effect. Protease inhibitors …

… that SARS-CoV M pro and SARS-CoV-2 M pro exhibit … the SARS-CoV main proteases as
well as tetrapeptide inhibitors. Further, we present a crystal structure of the SARS-CoV-2 M pro …

… of selectively inhibiting the SARS-CoV-2 M pro activity have been … inhibition. Therefore, this
review is focused on the structure of the SARS-CoV-2 M pro and the discovery of its inhibitors …