An mRNA vaccine against SARS-CoV-2—preliminary report

LA Jackson, EJ Anderson, NG Rouphael… - New England journal …, 2020 - Mass Medical Soc
… the mRNA-1273 SARS-CoV-2 vaccine encoding a stabilized prefusion spike trimer, S-2P.
Experience with the mRNA platform for other candidate vaccines … clinical vaccine candidate in …

SARS-CoV-2 mRNA vaccines: immunological mechanism and beyond

E Bettini, M Locci - Vaccines, 2021 - mdpi.com
… of the immune responses elicited by SARS-CoV-2 mRNA vaccines, built on the data from …
mRNA vaccine uptake/biodistribution and the innate immune response to mRNA vaccines are …

[HTML][HTML] An evidence based perspective on mRNA-SARS-CoV-2 vaccine development

F Wang, RM Kream, GB Stefano - Medical science monitor …, 2020 - ncbi.nlm.nih.gov
… However, there remain significant challenges in the development and testing of vaccines as
… of mRNA-based SARS-CoV-2 vaccines and the current status of the mRNA-1273 vaccine. …

mRNA vaccine-elicited antibodies to SARS-CoV-2 and circulating variants

Z Wang, F Schmidt, Y Weisblum, F Muecksch… - Nature, 2021 - nature.com
… We conclude that the plasma neutralizing activity elicited by mRNA vaccination or natural …
that are found in emerging variants of SARS-CoV-2. Vaccine-elicited monoclonal antibodies …

[HTML][HTML] SARS-CoV-2 mRNA vaccine design enabled by prototype pathogen preparedness

KS Corbett, DK Edwards, SR Leist, OM Abiona… - Nature, 2020 - nature.com
mRNA-1273, an mRNA vaccine that encodes a SARS-CoV-2 spike protein that is stabilized
in the prefusion conformation. Here we show that mRNA-… D614G mutant 2 SARS-CoV-2 as …

Efficacy and safety of the mRNA-1273 SARS-CoV-2 vaccine

LR Baden, HM El Sahly, B Essink… - New England journal …, 2021 - Mass Medical Soc
… The Coronavirus Efficacy (COVE) phase 3 trial … mRNA-1273 vaccine in preventing SARS-CoV-2
infection. An independent data and safety monitoring board determined that the vaccine

mRNA vaccine: How to meet the challenge of SARS-CoV-2

Y Jin, C Hou, Y Li, K Zheng, C Wang - Frontiers in immunology, 2022 - frontiersin.org
… As an emerging technology, mRNA vaccine is widely … SARS-CoV-2 vaccines, specifically
mRNA vaccines, focusing on the challenges of developing mRNA vaccines against SARS-CoV-…

Impact of circulating SARS-CoV-2 variants on mRNA vaccine-induced immunity

C Lucas, CBF Vogels, I Yildirim, JE Rothman, P Lu… - Nature, 2021 - nature.com
vaccination and/or SARS-CoV-2 infection fare against emerging virus variants, we assembled
a cohort of mRNA-vaccinated … We found that mRNA vaccines induced high titres of virus-…

Safety and immunogenicity of SARS-CoV-2 variant mRNA vaccine boosters in healthy adults: an interim analysis

A Choi, M Koch, K Wu, L Chu, LZ Ma, A Hill, N Nunna… - Nature medicine, 2021 - nature.com
… complications of Coronavirus Disease 2019 (… by mRNA vaccines 12 . Furthermore, a rapid
anamnestic response might be generated upon subsequent exposure to VOCs by vaccination-…

A novel receptor-binding domain (RBD)-based mRNA vaccine against SARS-CoV-2

W Tai, X Zhang, A Drelich, J Shi, JC Hsu, L Luchsinger… - Cell research, 2020 - nature.com
… antigen to design effective vaccines against SARS-CoV-2, indicating great potential of
RBD-based mRNA vaccine for mitigation of the COVID-19 pandemic and possible SARS-related …