[HTML][HTML] Epistasis lowers the genetic barrier to SARS-CoV-2 neutralizing antibody escape

L Witte, VA Baharani, F Schmidt, Z Wang, A Cho… - Nature …, 2023 - nature.com
neutralizing receptor binding domain (RBD)-specific antibodies with activity against emergent
variants. To determine how SARS-CoV-2 might escape … 40 broadly neutralizing antibodies. …

[HTML][HTML] Atlas of currently available human neutralizing antibodies against SARS-CoV-2 and escape by Omicron sub-variants BA. 1/BA. 1.1/BA. 2/BA. 3

M Huang, L Wu, A Zheng, Y Xie, Q He, X Rong, P Han… - Immunity, 2022 - cell.com
neutralize Omicron pseudoviruses. Moreover, to reveal molecular mechanism of immune
escape … -1, RBD-5, and RBD-7) with different neutralizing potencies. Our data demonstrate the …

[HTML][HTML] Multiple SARS-CoV-2 variants exhibit variable target cell infectivity and ability to evade antibody neutralization

H Tang, L Gao, Z Wu, F Meng, X Zhao, Y Shao… - Frontiers in …, 2022 - frontiersin.org
… and antigenicity of SARS-CoV-2, leading to the immune escape from those neutralizing
antibodies. … system was used to assess the infectivity and immune escape. We found that some …

Antibody cocktail to SARS-CoV-2 spike protein prevents rapid mutational escape seen with individual antibodies

A Baum, BO Fulton, E Wloga, R Copin, KE Pascal… - Science, 2020 - science.org
… To functionally confirm that the spike protein mutations detected by sequencing are
responsible for the loss of SARS-CoV-2 neutralization by the antibodies, we generated VSV-…

[HTML][HTML] SARS-CoV-2 variant Omicron: currently the most complete “escapee” from neutralization by antibodies and vaccines

M Li, F Lou, H Fan - Signal Transduction and Targeted Therapy, 2022 - nature.com
… However, the emergence of Omicron variant with high infectivity and immune escape
ability … -binding domain (RBD) escaping mutation profile for 247 neutralizing antibodies (NAbs) …

[HTML][HTML] The global epidemic of the SARS-CoV-2 delta variant, key spike mutations and immune escape

D Tian, Y Sun, J Zhou, Q Ye - Frontiers in immunology, 2021 - frontiersin.org
… Vaccines induce neutralizing antibodies against the SARS-CoV-2 and induce a T cell
response against the virus. Animal experiments have shown that a single intramuscular injection …

[HTML][HTML] Immune escape associated with RBD Omicron mutations and SARS-CoV-2 evolution dynamics

AV Kudriavtsev, AV Vakhrusheva, VN Novoseletsky… - Viruses, 2022 - mdpi.com
… data are in accordance with the quantity of significant RBD mutations that provide escape
from neutralizing antibodies. In Table 2, the most significant RBD mutations responsible for …

[HTML][HTML] Parallel profiling of antigenicity alteration and immune escape of SARS-CoV-2 Omicron and other variants

C Sun, YF Kang, YT Liu, XW Kong, HQ Xu… - … and Targeted Therapy, 2022 - nature.com
neutralizing antibody or receptor with wild-type SARS-CoV-2 … By specifying mutations from
different SARS-CoV-2 variants, … immune escape effect in a pseudovirus neutralization assay (…

Recurrent deletions in the SARS-CoV-2 spike glycoprotein drive antibody escape

KR McCarthy, LJ Rennick, S Nambulli… - Science, 2021 - science.org
… that both viral stocks could be neutralized efficiently. These data demonstrate that … SARS-CoV-2
have altered antigenicity. We used a range of high-, medium-, and low-titer neutralizing

[HTML][HTML] Structural and functional characterizations of infectivity and immune evasion of SARS-CoV-2 Omicron

Z Cui, P Liu, N Wang, L Wang, K Fan, Q Zhu, K Wang… - Cell, 2022 - cell.com
… Severe acute respiratory syndrome coronavirus 2 (SARS-CoV… infectivity, and immune escape
as observed among emerging … basis for neutralization of SARS-CoV-2 and SARS-CoV by a …