[PDF][PDF] Circulating SARS-CoV-2 variants escape neutralization by vaccine-induced humoral immunity

WF Garcia-Beltran, EC Lam, KS Denis, AD Nitido… - medRxiv, 2014 - scienceopen.com
… To understand the impact of globally circulating variants, we evaluated the neutralization
10 strains of SARSCoV-2. While multiple strains exhibited vaccine-induced cross-neutralization

Neutralization of SARS-CoV-2 lineage B. 1.1. 7 pseudovirus by BNT162b2 vaccine–elicited human sera

A Muik, AK Wallisch, B Sänger, KA Swanson, J Mühl… - Science, 2021 - science.org
… recognition by neutralizing antibodies may be affected. In this study, we tested SARS-CoV-2-…
sera makes it unlikely that the UK variant virus will escape BNT162b2-mediated protection. …

Discovery of ultrapotent broadly neutralizing antibodies from SARS-CoV-2 elite neutralizers

K Vanshylla, C Fan, M Wunsch, N Poopalasingam… - Cell host & …, 2022 - cell.com
… Several isolated broadly neutralizing antibodies were effective against B.1.1.7, B.… escape
sites. Furthermore, assembly of 716,806 SARS-CoV-2 sequences predicted emerging escape

Crucial mutations of spike protein on SARS-CoV-2 evolved to variant strains escaping neutralization of convalescent plasmas and RBD-specific monoclonal …

C Ding, J He, X Zhang, C Jiang, Y Sun… - Frontiers in …, 2021 - frontiersin.org
… The phenomenon of a decreased neutralization activity of some … SARS-CoV-2 replication
and to avoid immune escape. A potential limitation of this study lies in the lack of neutralization

Omicron: a heavily mutated SARS-CoV-2 variant exhibits stronger binding to ACE2 and potently escapes approved COVID-19 therapeutic antibodies

M Shah, HG Woo - Frontiers in immunology, 2022 - frontiersin.org
… acids adjacent to those predicted to escape the neutralization of antibodies. … neutralization
(Figure 3E). During our study, two research groups investigated the neutralization escape of …

Structural basis for continued antibody evasion by the SARS-CoV-2 receptor binding domain

KG Nabel, SA Clark, S Shankar, J Pan, LE Clark… - Science, 2021 - science.org
… To identify evolutionary barriers that restrict neutralization breadth, we used the SARS-CoV
Our findings portend continued emergence of escape variants as SARS-CoV-2 adapts to …

A human coronavirus evolves antigenically to escape antibody immunity

RT Eguia, KHD Crawford, T Stevens-Ayers… - PLoS …, 2021 - journals.plos.org
… Here we experimentally assess whether coronavirus 229E escapes neutralization by human
polyclonal sera by reconstructing the virus’s evolution over the last several decades. We …

SARSCoV‐2 Omicron variant: Immune escape and vaccine development

D Ao, T Lan, X He, J Liu, L Chen, DT Baptista‐Hon… - MedComm, 2022 - Wiley Online Library
… Q493R substitutions participated in the escape of antibody neutralization of the Omicron
variant. In … of escape from neutralization when compared with the ancestral SARS-CoV-2 strain. …

Broadly neutralizing antibodies overcome SARS-CoV-2 Omicron antigenic shift

E Cameroni, JE Bowen, LE Rosen, C Saliba… - Nature, 2022 - nature.com
… —escape from mRNA-vaccine-elicited neutralizing antibodies. Another report also shows
that vaccine effectiveness against symptomatic disease induced by the Omicron variant is …

Homologous or heterologous booster of inactivated vaccine reduces SARS-CoV-2 Omicron variant escape from neutralizing antibodies

X Wang, X Zhao, J Song, J Wu, Y Zhu, M Li… - Emerging microbes & …, 2022 - Taylor & Francis
… the fold of reduction of neutralization against WT strain and … can reduce the Omicron escape
from neutralizing antibodies. … neutralization profile of a panel of mAbs targeting SARS-CoV-2 …