High genetic barrier to SARS-CoV-2 polyclonal neutralizing antibody escape

F Schmidt, Y Weisblum, M Rutkowska, D Poston… - Nature, 2021 - nature.com
… -associated and antibody-selected spike … in the SARS-CoV-2 spike protein are sufficient to
generate pseudotypes with near-complete resistance to the polyclonal neutralizing antibodies

Cross-reactive neutralizing antibody responses elicited by SARS-CoV-2 501Y. V2 (B. 1.351)

T Moyo-Gwete, M Madzivhandila… - … England Journal of …, 2021 - Mass Medical Soc
… previous SARS-CoV-2 infection. We first assessed the binding and neutralizing antibody
responses … for the elicitation of cross-reactive neutralizing antibody responses to SARS-CoV-2. …

Neutralizing antibodies against SARS-CoV-2: current understanding, challenge and perspective

Y Huang, H Sun, H Yu, S Li, Q Zheng… - Antibody …, 2020 - academic.oup.com
antibody-dependent enhancement and viral escape mutations. Such evidence is urgently
needed to the development of antibody … development of SARS-CoV-2 neutralizing antibodies (…

[HTML][HTML] Human neutralizing antibodies against SARS-CoV-2 require intact Fc effector functions for optimal therapeutic protection

ES Winkler, P Gilchuk, J Yu, AL Bailey, RE Chen… - Cell, 2021 - cell.com
… Although passively delivered neutralizing antibodies against SARS-CoV-2 show promise
in … of protection of neutralizing human monoclonal antibodies (mAbs) in SARS-CoV-2-infected …

[HTML][HTML] Humoral immune responses and neutralizing antibodies against SARS-CoV-2; implications in pathogenesis and protective immunity

J Carrillo, N Izquierdo-Useros, C Ávila-Nieto… - Biochemical and …, 2021 - Elsevier
… Given the key role of antibodies in protection from … on antibodies against SARS-CoV-2, their
implications in our understanding of disease pathogenesis, and the development of antibody

Dynamics of SARS-CoV-2 neutralising antibody responses and duration of immunity: a longitudinal study

WN Chia, F Zhu, SWX Ong, BE Young, SW Fong… - The Lancet …, 2021 - thelancet.com
… of neutralising antibodies for SARS-CoV-2. We aimed to investigate the peak levels and
dynamics of neutralising antibody … of clinical characteristics with neutralizing antibody levels in …

A proof of concept for neutralizing antibody-guided vaccine design against SARS-CoV-2

L Zhang, L Cao, XS Gao, BY Zheng… - National Science …, 2021 - academic.oup.com
… (RBD) that make neutralizing epitopes momentarily unavailable present … coronavirus 2
(SARS-CoV-2). To mitigate viral escape, we developed a cocktail of neutralizing antibodies (NAbs…

[HTML][HTML] Neutralizing antibodies against the SARS-CoV-2 Delta and Omicron variants following heterologous CoronaVac plus BNT162b2 booster vaccination

E Pérez-Then, C Lucas, VS Monteiro, M Miric… - Nature medicine, 2022 - nature.com
neutralizing antibody escape against the Omicron variant after vaccination. In the HCW
cohort we observed a 14.5-fold reduction in neutralization … (the peak of neutralization titers 8 ), …

Perspectives on the development of neutralizing antibodies against SARS-CoV-2

M Ho - Antibody therapeutics, 2020 - academic.oup.com
… Fc engineering for developing neutralizing antibodies for treating … of SARS-CoV-2 neutralizing
antibodies and provides several representative examples using these methods. Antibody

[HTML][HTML] A potently neutralizing antibody protects mice against SARS-CoV-2 infection

WB Alsoussi, JS Turner, JB Case, H Zhao… - The Journal of …, 2020 - journals.aai.org
… -CoV and MERS-CoV RBD. Because binding is not an … had neutralizing activity against
SARS-CoV-2 strain 2019 n-CoV/… ) displayed strong neutralizing activity against SARS-CoV-2. …