… SARS-CoV nsp12 polymerase bound to its essential co-factors, nsp7 and nsp8, using single
particle cryo-electron microscopy. nsp12 … of SARS-CoV nsp12 to the polymerase proteins of …

… Recently emerged SARS-CoV-2 caused a major outbreak of coronavirus disease 2019 (…
that specifically target SARS-CoV-2 vital proteins, including the main protease, Nsp12 RNA …

… Taken together, we demonstrate that SARS-CoV-2 NSP12 protein does not antagonize
IFN-β production, which is supported by the results that neither the phosphorylation or nuclear …

… an nsp12 fusion protein and its in vivo cleavage to generate and purify stable SARS-CoV
nsp12 … This recombinant protein possesses robust in vitro RdRp activity, as well as a significant …

… of the SARS-CoV RdRp and ExoN proteins, as well as Lassa virus N exonuclease to derive
… , we show here that the related Lassa virus N protein ExoN domain for which this type of data …

… the SARS-CoV-2 polymerase complex consisting of the nsp12 catalytic subunit and nsp7-nsp8
cofactors. This structure highly resembles the counterpart of SARS-CoV … The three protein …

… the underlying mechanisms of different proteins of SARS-CoV-2 that … We also described
different viral proteins inhibiting the … The induction of NSP12 does not affect the production of IFN-…

… protein, N, and 3 Nsps that included Nsp15, Nsp-9, and the main protease ([Mpro] Nsp5) of
SARSCoV-2 that were recently released by the protein … Structure of the SARS-CoV nsp12 …

… , ORF8, ORF8a, ORF9b, ORF14) found in the Y2H system eight could be confirmed by
CoIP (nsp2, nsp7, nsp8, nsp9, nsp12, nsp13, nsp14, E protein). Nsp 8 and nsp12 proteins …

… We postulate that these “early” viral proteins, including nsp12, may help to antagonize
the host innate immune response triggered by incoming viral RNAs or other signals at the …