… safety and optimal dose of … -dose, Phase Ib/IIa platform in the UK using a seamless Bayesian
adaptive design 2 to determine the safety, activity and optimal dose of multiple SARS-CoV-…

… The present study aimed to define the optimal doses and schedules for maintaining tizoxanide
plasma and lung concentrations above the reported nitazoxanide EC 90 for the duration …

… We calibrated statistical models to published dose-… (Ad5) SARS-CoV-2 vaccine given at
doses 5.0 × 10 10 , 1.0 × 10 11 and 1.5 × 10 11 viral particles. We estimated the optimal dose for …

… shows that the proper dosing interval and drug dose both are … studied as a possible drug
dosing policy. To reactivate the … optimal dosing regimen for which infection can be controlled. …

… vaccination will receive two doses. While optimal dose timing can substantially reduce the
… For a given number of doses, we sought the optimal deployment of a mixed scheme where …

… , we introduce a mathematical model that rigorously describes a two-dose vaccination
scheme and optimal allocation of vaccines through delay differential equations. We explore the …

… The COVID-19 vaccines currently in use require 2 doses to achieve optimal protection.
Currently, there is no indication as to whether individuals who have been exposed to …

… -term SARS-CoV-2 infection and immunity dynamics contingent on vaccine dosing regimes.
… is also optimal from an epidemiological perspective in the longer term. On the other hand, if …

… While the optimal dosing strategy of thiamine is unclear, based on the work of Donnino et
al we suggest a dose of 200 mg IV 12 hourly for 7 day [Citation43], followed by oral thiamine …

… pros and cons of dose-sparing strategies. Because delaying the second dose increases the
… However, vaccine supply shortages have sparked a debate about the optimal distribution of …