… pros and cons of dose-sparing strategies. Because delaying the second dose increases the
… However, vaccine supply shortages have sparked a debate about the optimal distribution of …

… i Define the optimal drug dose(s) and frequency to achieve unbound concentrations in plasma
and tissue to maximise antiviral and/or disease suppressing activity. For antivirals, this will …

… do not allow the identification of an optimal dose to guarantee the safety and efficacy of
chloroquine. Further results from ongoing studies will be needed to outline the optimal dose. …

… safety of a SARS-CoV-2 inactivated vaccine (CoronaVac). METHODS We conducted a
randomized, double-blind, placebo-controlled trial to evaluate the optimal dose, immunogenicity …

… A 7-8-week interval between doses improved VE and may be optimal in … dose SARS-CoV-2
VE against infection and hospitalization, including with mixed vaccines and extended dosing …

… from individuals receiving two doses of the Pfizer vaccine showed a non-significant increase
in binding to SARS-CoV-2 spike and RBD compared to those receiving single dose and a …

… the optimal antigen formulation and dose. … dose levels administered in a 0·5 mL vaccine
dose in this study were 1·3 μg (low dose) and 2·6 μg (high dose) of functional SARS-CoV-2 preS …

… treatments seem to compromise optimal antibody responses following SARS-CoV-vaccination
(… individuals after the first vaccine dose developed antibodies against SARS-CoV-2 virus, …

… The aim of the present preliminary study was to carry out SARS-CoV-2 wild type MN assay
in order to investigate which optimal tissue culture infective dose 50 (TCID 50 ) infective dose …

… Focusing on adults with early symptomatic COVID-19, the optimal dose and safety of
molnupiravir were evaluated through a multicenter, multistage, open-label, phase-Ib/IIa randomized …