Optimal dose and safety of molnupiravir in patients with early SARS-CoV-2: a Phase I, open-label, dose-escalating, randomized controlled study

SH Khoo, R Fitzgerald, T Fletcher… - Journal of …, 2021 - academic.oup.com
… In this trial (NCT04746183) we evaluated the safety and optimal dose of … safety and tolerability
of multiple ascending doses of molnupiravir in participants with PCR-confirmed SARS-CoV

Optimising vaccine dose in inoculation against SARS-CoV-2, a multi-factor optimisation modelling study to maximise vaccine safety and efficacy

J Benest, S Rhodes, M Quaife, TG Evans, RG White - Vaccines, 2021 - mdpi.com
… is novel in its inclusion of dose-safety and dose-cost models and … to hypothesize the best
dosing for a candidate SARS-CoV-2 … Finally, the dose-seroconversion and dose-safety models …

Immunogenicity and safety of a SARS-CoV-2 inactivated vaccine in healthy adults aged 18-59 years: report of the randomized, double-blind, and placebo-controlled …

Y Zhang, G Zeng, H Pan, C Li, B Kan, Y Hu, H Mao… - medrxiv, 2020 - medrxiv.org
safety of a SARS-CoV-2 inactivated vaccine (CoronaVac). … to evaluate the optimal dose,
immunogenicity and safety of the … 2 injections of the trial vaccine at a dose of 3 μg/0.5 mL or 6 μg …

Safety and immunogenicity of SARS-CoV-2 recombinant protein vaccine formulations in healthy adults: interim results of a randomised, placebo-controlled, phase 1–2 …

PA Goepfert, B Fu, AL Chabanon… - The Lancet Infectious …, 2021 - thelancet.com
… being developed against SARS-CoV-2. We present interim safety and immunogenicity results
of the … candidate vaccine will focus on identifying the optimal antigen formulation and dose. …

A call for the appropriate application of clinical pharmacological principles in the search for safe and efficacious COVID-19 (SARS-COV-2) treatments.

EH Baker, D Gnjidic, CMJ Kirkpatrick… - Br J Clin …, 2021 - openaccess.sgul.ac.uk
… i Define the optimal drug dose(s) and frequency to achieve unbound concentrations in plasma
and tissue to maximise antiviral and/or disease suppressing activity. For antivirals, this will …

Camostat mesylate against SARSCoV‐2 and COVID‐19—Rationale, dosing and safety

P Breining, AL Frølund, JF Højen… - Basic & clinical …, 2021 - Wiley Online Library
… When used in the treatment of acute worsening of chronic pancreatitis or postoperative
reflux oesophagitis, the recommended dosage is 300-600 mg/day in three dosages of 100-200 …

… dosages as adjunctive therapy of hospitalized patients with severe respiratory syndrome in the context of coronavirus (SARS-CoV-2) infection: Preliminary safety …

MG Silva Borba, FF Almeida Val, VS Sampaio… - MedRxiv, 2020 - medrxiv.org
… Due to the impossibility of not using the drug recommended at the national … dosage of CQ
(12 g total dose over 10 days) in COVID-19 should not be recommended because of safety

[HTML][HTML] Humoral and cellular immune response and safety of two-dose SARS-CoV-2 mRNA-1273 vaccine in solid organ transplant recipients

VG Hall, VH Ferreira, M Ierullo, T Ku, T Marinelli… - American Journal of …, 2021 - Elsevier
… of immune protection from symptomatic SARS-CoV-2 infection … ) received both doses of the
vaccine at the recommended 1-… the first dose and so did not receive a second dose. Baseline …

[HTML][HTML] Safety and immunogenicity after a three-dose SARS-CoV-2 vaccine schedule in allogeneic stem cell transplant recipients

M Kimura, VH Ferreira, S Kothari, I Pasic… - … and cellular therapy, 2022 - Elsevier
… in similar studies demonstrating the safety of a 2-dose schedule. Second, we … recommended
the 3-dose schedule. Most of the participants had already received 2 doses of SARS-CoV-2 …

Two-dose SARS-CoV-2 vaccine effectiveness with mixed schedules and extended dosing intervals: test-negative design studies from British Columbia and Quebec …

DM Skowronski, S Setayeshgar, Y Febriani, M Ouakki… - MedRxiv, 2021 - medrxiv.org
… of mRNA and/or ChAdOx1 vaccines gave excellent protection against … doses improved VE
and may be optimal in most circumstances. Findings indicate prolonged two-dose protection