The spike proteins of SARS-CoV-2 B. 1.617 and B. 1.618 variants identified in India provide partial resistance to vaccine-elicited and therapeutic monoclonal …

T Tada, H Zhou, BM Dcosta, MI Samanovic… - BioRxiv, 2021 - biorxiv.org
partially resistant to neutralization by convalescent serum antibody and vaccine-elicited
antibodies. The resistance … In addition, the variants were partially resistant to REGN10933, one …

Partial resistance of SARS-CoV-2 Delta variants to vaccine-elicited antibodies and convalescent sera

T Tada, H Zhou, BM Dcosta, MI Samanovic… - Iscience, 2021 - cell.com
… The B.1.617 and B.1.618 variants were partially resistant to REGN10933, … partially resistant
to the antibody cocktail. Viruses with the B.1.617 and B.1.618 spikes were partially resistant

In vitro selection of Remdesivir resistance suggests evolutionary predictability of SARS-CoV-2

AM Szemiel, A Merits, RJ Orton, OA MacLean… - PLoS …, 2021 - journals.plos.org
SARS-CoV-2 RDV resistance in patients, animal models or in vitro. Here, we selected
drug-resistant viral populations by serially passaging SARS-CoV-2 … mutation into our SARS-CoV-2 …

Resistance of SARS-CoV-2 variants to neutralization by convalescent plasma from early COVID-19 outbreak in Singapore

B Wang, YS Goh, T Prince, EZX Ngoh, SNM Salleh… - npj Vaccines, 2021 - nature.com
… from a prior SARS-CoV-2 infection is specific for the WT strain or is able to detect other
strains, we applied the SFB assay to detect antibodies against S protein of other SARS-CoV-2 …

[HTML][HTML] Novel SARS-CoV-2 variants: the pandemics within the pandemic

E Boehm, I Kronig, RA Neher, I Eckerle, P Vetter… - Clinical Microbiology …, 2021 - Elsevier
Background Many new variants of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
have been termed variants of concern/interest (VOC/I) because of the greater risk …

The global epidemic of SARSCoV‐2 variants and their mutational immune escape

D Tian, YH Sun, JM Zhou, Q Ye - Journal of medical virology, 2022 - Wiley Online Library
… N3 loop led to partial resistant to the neutralization activity of … generated a complete resistance
to the neutralization activity … mutations in the NTD was most resistant to current mAbs and …

In vitro evolution of Remdesivir resistance reveals genome plasticity of SARS-CoV-2

AM Szemiel, A Merits, RJ Orton, O MacLean, RM Pinto… - BioRxiv, 2021 - biorxiv.org
… signatures within the genome of SARS-CoV-2 which lead to resistance (or partial resistance)
to RDV. We should consider that our partially-resistant RDV populations arose rapidly with …

Nirmatrelvir-resistant SARS-CoV-2 is efficiently transmitted in female Syrian hamsters and retains partial susceptibility to treatment

R Abdelnabi, D Jochmans, K Donckers, B Trüeb… - Nature …, 2023 - nature.com
… available yet about emergence of resistant virus variants to molnupiravir or … a SARS-CoV-2
resistant virus against a first generation 3CLpro inhibitor (ALG-097161) that is cross-resistant

[HTML][HTML] Increased resistance of SARS-CoV-2 variant P. 1 to antibody neutralization

P Wang, RG Casner, MS Nair, M Wang, J Yu… - Cell host & …, 2021 - cell.com
… Here we report that P.1 is indeed resistant to neutralization by several RBD-directed
mAbs, including three with EUA. The major culprit is the E484K mutation, which has emerged …

[HTML][HTML] SARS-CoV-2 variants B. 1.351 and P. 1 escape from neutralizing antibodies

M Hoffmann, P Arora, R Groß, A Seidel, BF Hörnich… - Cell, 2021 - cell.com
… may alter virus-host cell interactions and confer resistance to inhibitors and antibodies. Here,
… .1 variant was partially (Casirivimab) or fully (Bamlanivimab) resistant to antibodies used for …