… achieved in searching for drugs inhibiting the M pro , … potentialinhibitors targeting SARS-CoV-2 M pro , identifies gaps, and provides future directions. Further, compounds with potential …
… inhibitors of COVID-19 protease, there is a demand to conduct a comprehensive review of the most important studies to reveal and compare the potential … for adjusting antiviral inhibitors, …
ST Ngo, N Quynh Anh Pham, L Thi Le… - Journal of chemical …, 2020 - ACS Publications
… We also found that Glu166 forms H-bonds to all of the inhibitors. Replacing … to SARS-CoV-2 Mpro. Our results could contribute to the development of potential drugs inhibitingSARS-CoV…
Y Han, Z Wang, J Ren, Z Wei, J Li - Briefings in Bioinformatics, 2021 - academic.oup.com
… SARS-CoV-2 after intravenous treatment [12], while Chloroquine and Hydroxychloroquine are being reported to be potentialinhibitors of SARS-CoV-2 … its efficacy against SARS-CoV-2. …
F Touret, M Gilles, K Barral, A Nougairède… - Scientific reports, 2020 - nature.com
… inhibitors, antiarrhythmic agents or CNS drugs emerged showing antiviral potency with 2 < EC50 ≤ 20 µM. By providing new information on molecules inhibitingSARS-CoV-… SARS-CoV-…
… The inhibition of the SARS-CoV-2 main protease is necessary … to identify the possible inhibitors of the SARS-CoV-2 main … bind to the active site of the SARS-CoV-2 protease (PDB: …
AT Ton, F Gentile, M Hsing, F Ban… - Molecular …, 2020 - Wiley Online Library
… molecule therapeutics for SARS-CoV-2. Along these efforts, the structure of SARS-CoV-2 main … ZINC15 library to identify top 1,000 potential ligands for SARS-CoV-2 Mpro protein. The …
… -7-glucoside-4′-neohesperidoside as potentialinhibitors of Mpro and PLpro, respectively. Other studies have also reported rutin as SARS-CoV-2 Mpro inhibitor (Huynh et al., 2020, …
… Its genome is about 82% identical to the SARScoronavirus (SARS-CoV). Specifically… Potentially, it can block the binding of RBD to ACE2 and hence it can be used as a potentialinhibitor…