… protease by disrupting the M pro dimer. The present study assesses the M pro mutants of
emerging SARS-CoV… We analyzed the most widespread amino acid substitutions in SARS-CoV-…

… The emergence of SARS-CoV-2 variants with mutations in M pro raised the alarm of … -resistant
mutants, we systematically characterized 102 naturally occurring M pro mutants located at …

… m /V max of SARS-CoV-2 3CL pro mutants, proteolytic reactions were … SARS-CoV-2 3CL
pro mutants were used as an enzyme source and the synthesized peptide between SARS-CoV-…

… distinguishing features of SARS-CoV-2, and some of the characteristics of the mutant viruses
seem … Changes in cleavage properties and the proteases available for cleavage can cause …

… We compiled a list of 3CL pro mutations which have been associated with nirmatrelvir or
ensitrelvir … We analyzed the prevalence for different time periods, SARS-CoV-2 lineages and …

… further investigation on the mutants of SARS-CoV-2 M pro … mutants from SARS-CoV-2
variants and analyzed their susceptibility to inhibition by nirmatrelvir. These documented mutations …

… interaction of paxlovid, and the emergence of SARS-CoV-2 variants with potential drug-resistant
mutations, there is a pressing need for additional antivirals to combat current and future …

… a multitude of 3CL protease mutations. In the experiment … lineages were selected with
mutations observed at 23 different … the mutations identified in this study with clinical SARS-CoV-…

… Despite the comparable efficacy of nirmatrelvir against the wild-type protease and its point
mutants or variants in different virus strains, currently, we only have information about the PI-…

… study that the D614G mutation enhances susceptibility of the SARS-CoV-2 S … SARS-CoV-2
S D614G mutation on S structure, focusing on RBD conformation and changes in proteolytic …