… Like other viruses, SARS-CoV-2, have also acquired unique mutations. These mutations
within … In the present study we identified important active site mutations within the SARS-CoV-2 …

… Selection for nirmatrelvir resistance resulted in the appearance of L167F in the absence
of other mutations, and an engineered SARS-CoV-2 infectious clone with only the L167F …

… We explore how amino acid mutations affect the stability of the 306 residue main … to
elucidate the effects of single mutations on the stability of the main protease (Mpro) of SARS-CoV-2. …

… viruses, SARS-CoV-2 could acquire mutations in its main protease (M … mutations in M pro
already exist in the globally circulating SARS-CoV-2 lineages and several predicted mutations. …

… SARS-CoV-2 but other coronavirus infections as well. While the 3CL protease has been
studied by many groups for SARS-CoV-… of its tolerance to mutations is limited, knowledge which …

… cells confirmed that the S2′ mutations have minor impact on … SARS-CoV-2 spike activation
by these two airway proteases, … motif changes as they appear in new SARS-CoV-2 variants. …

… Therefore, tracing the mutations occurring in SARS-CoV-2 viral components … mutations of
M pro found in 5 VOCs of SARS-CoV-2. We identified hot spots that had an effect on protease …

… a monomeric catalytic domain of SARS CoV-2 main protease (MPro) from an … mutant, unlike
H41A, increases by 6.8 C, relative to wild-type mature dimer. An inactivating H41A mutation …

… (Mpro) sequence is substantially conserved across coronavirus … from SARS CoV-2 has a
sequence similarity of more than 96% to the same protease identified in MERS and SARS CoV-…

… find that SARS-CoV-2 is slightly more infectious than SARS-CoV … mutations on the S
protein receptor-binding domain, we show that most likely future mutations will make SARS-CoV-2 …