… data which pinpoint the cognate furin site mutations. We urge the field to be … SARS-CoV-2
entry is highly dependent on the interplay between cleavage site mutations and the proteases …

… The main protease (Mpro) plays a vital role in proteolytic … the replicative cycle of SARS
coronavirus (SARS-CoV). Dimerization … mutations on the dimer interface of SARS coronavirus 3C-…

… However, none these variants contain mutations that are in the vicinity of the active site.
Herein, we evaluated the effect of single mutations in the active site of M pro from circulating …

… Overall, the detection of all mutations in SARS-CoV-2 and … mutations of the SARS-CoV-2
and related variations in virus … virus enters the host cell cytosol by transmembrane protease …

… However, all mutants show similar drug resistance phenotypes when combined with P132H
… that these mutations are capable of conferring resistance to protease inhibitors in the context …

… the mutant protease and determined the structure of E166V in complex with nirmatrelvir. In
vitro biochemical testing of the E166V mutant … activity of the E166V mutant in cleaving this …

… SARS-CoV 3CL proteinase have been reported previously ( 29). The H41A, C145A, C145S
mutants in SARS-CoV 3CL proteinase … The mutations were verified by sequencing. The 3CL …

… Using this analysis system, we separately examined the effects of various mutations of the
… This mechanism appears to exist only in the SARS-CoV 3CL protease. However, there may …

… severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) … The viral main protease
(M pro ) plays an important role in … protease inhibitors can lead to the development of mutants …

… acids, is the most aggressive mutant amino acid for stronger … forces that trigger mutations in
the SARS-CoV-2 virus. It also … for blocking critical amino acids of mutants, such as arginine, in …