Identification and functional analysis of the SARS-COV-2 nucleocapsid protein

T Gao, Y Gao, X Liu, Z Nie, H Sun, K Lin, H Peng… - BMC microbiology, 2021 - Springer
… In this study, we primary analyzed the SARS-COV-2 N protein which was a 45.6 kDa,
positively charged, unstable hydrophobic protein with poor heat resistance protein mainly …

Analysis of intraviral protein-protein interactions of the SARS coronavirus ORFeome

A von Brunn, C Teepe, JC Simpson, R Pepperkok… - PloS one, 2007 - journals.plos.org
SARS-CoV protein on both the N- and C- terminus and only considered the cellular localization
correct if consistent with both tags [30]. Some of the proteins … not included in the analysis. …

[HTML][HTML] Structural and functional analysis of the D614G SARS-CoV-2 spike protein variant

L Yurkovetskiy, X Wang, KE Pascal, C Tomkins-Tinch… - Cell, 2020 - cell.com
… The SARS-CoV-2 spike (S) protein variant D614G supplanted the ancestral virus
worldwide… D614G did not alter S protein synthesis, processing, or incorporation into SARS-CoV-2 …

Structural analysis of SARS-CoV-2 ORF8 protein: pathogenic and therapeutic implications

A Valcarcel, A Bensussen, ER Álvarez-Buylla… - Frontiers in …, 2021 - frontiersin.org
… despite there are other viral proteins with important roles in COVID-19 pathogenicity. For …
mitogen-activated protein kinases (MAPKs). In this mini-review, we analyze the main structural …

Genome-wide analysis of protein-protein interactions and involvement of viral proteins in SARS-CoV replication

JA Pan, X Peng, Y Gao, Z Li, X Lu, Y Chen, M Ishaq… - PloS one, 2008 - journals.plos.org
… and limited information is available on viral protein-protein networks of coronaviruses [50]. …
of individual proteins, we analyzed interactions between all SARS-CoV-encoded proteins. By …

[HTML][HTML] Analysis of therapeutic targets for SARS-CoV-2 and discovery of potential drugs by computational methods

C Wu, Y Liu, Y Yang, P Zhang, W Zhong… - … Pharmaceutica Sinica B, 2020 - Elsevier
analyzed all the proteins encoded by SARS-CoV-2 genes, compared them with proteins
on the market and undergoing clinical trials for SARS-CoV-2 was constructed. Possible targets …

Human SARS CoV‐2 spike protein mutations

L Guruprasad - Proteins: Structure, Function, and Bioinformatics, 2021 - Wiley Online Library
… The mutations are present in 8155 proteins among 10333 human SARS-CoV-2 spike
protein sequences analyzed in the present work. The total number of mutations observed were …

Analysis of the SARS-CoV-2 spike protein glycan shield reveals implications for immune recognition

OC Grant, D Montgomery, K Ito, RJ Woods - Scientific reports, 2020 - nature.com
… (SARS) infection by a novel coronavirus (SARS-CoV-2) at the … of the SARS-CoV-2 envelope
spike (S) protein that mediates … Viral envelope proteins are often modified by the attachment …

[HTML][HTML] Comparative computational analysis of SARS-CoV-2 nucleocapsid protein epitopes in taxonomically related coronaviruses

B Tilocca, A Soggiu, M Sanguinetti, V Musella… - Microbes and …, 2020 - Elsevier
… of the investigated proteins. … with SARS-CoV-2 nucleocapsid proteins. These evidence
provide a molecular structural rationale for a potential role in conferring protection from SARS-CoV

Global analysis of protein-RNA interactions in SARS-CoV-2-infected cells reveals key regulators of infection

W Kamel, M Noerenberg, B Cerikan, H Chen… - Molecular cell, 2021 - cell.com
… that are involved in SARS-CoV-2 infection. We reveal that SARS-CoV-2 infection profoundly
… Moreover, we apply a new method to identify the proteins that directly interact with viral RNA…