… to the human ACE2 entry receptor with high affinity and can … receptor recognition, we
determined cryo–electron microscopy (cryo-EM) structures of the prefusion-stabilized SARS-CoV-2 …

… In addition, some auxiliary receptors and cofactors are also involved that expand the host/tissue
tropism of SARS-CoV-2. After receptor engagement, specific proteases are required that …

… SARS patients recognize the SARSCoV-S protein and neutralize infection. Transient expression
of SARS-CoV-S … from healthy patients or SARS patients revealed that SARS patient sera …

… cellular foundations for understanding the multistep SARS-CoV-2 entry process, including S
… of the S protein with ACE2, engagement of the receptor-binding domain of the S protein with …

… SARS-CoV-2 spike. These antibodies prevented viral receptor engagement by locking the
receptor… Deep mutational scanning showed that SARS-CoV-2 could mutate to escape 12-19, …

… hyperinflammatory responses To understand the effect of SARS-CoV-2 engagement with
myeloid cell receptors, we also used a recombinant SARSCoV-2 virus whose ORF7 was …

… In typical cell culture systems, SARS-CoV gains entry via clathrin and nonclathrin pathways
following receptor engagement [84, 85], but treatment of cells with trypsin and/or trypsin-like …

… , could enhance docking sites for SARS-CoV-2, leading to … that SARS-CoV-2 may employ
additional receptors to gain … engagement between TLR3 and the S protein of SARS-CoV-…

… shared by other SARS-CoV-2 … receptor engagement and the key residue of spike for
proteolytic activation, and uncovers a targetable mechanism for host cell infection by SARS-CoV…

The SARS-CoV-2 Omicron variant exhibits striking immune evasion and is spreading globally
at an unprecedented speed. Understanding the underlying structural basis of the high …