SARS-CoV-2 mutations and their viral variants

B Cosar, ZY Karagulleoglu, S Unal, AT Ince… - Cytokine & growth factor …, 2022 - Elsevier
… was triggered by the acquisition of the L452R mutation, which is markedly resistant to mAbs
[97,98]. More research is needed to determine whether this variant, known as CAL20C, is …

[HTML][HTML] Resistance mutations in SARS-CoV-2 Delta variant after sotrovimab use

R Rockett, K Basile, S Maddocks, W Fong… - … England Journal of …, 2022 - Mass Medical Soc
… The asterisks indicate two sampling time points in which a high-quality SARS-CoV-2 …
potential resistance mutations could not be revealed. All the patients in whom resistance mutations

[HTML][HTML] Resistance mutations in SARS-CoV-2 omicron variant in patients treated with sotrovimab

C Vellas, P Trémeaux, A Del Bello… - Clinical Microbiology …, 2022 - ncbi.nlm.nih.gov
… in half of the patients who remained SARS-CoV-2 RNA … emergence of SARS-CoV-2 variants
with mutation at positions … of Omicron variants harbouring mutations in these positions and a …

[HTML][HTML] Multiple pathways for SARS-CoV-2 resistance to nirmatrelvir

S Iketani, H Mohri, B Culbertson, SJ Hong, Y Duan… - Nature, 2023 - nature.com
… Finally, we compared the mutations identified in this study with clinical SARS-CoV-2
sequences reported to the Global Initiative on Sharing Avian Influenza Data 31 . Nearly all of the …

Mechanisms of SARS-CoV-2 evolution revealing vaccine-resistant mutations in Europe and America

R Wang, J Chen, GW Wei - The journal of physical chemistry …, 2021 - ACS Publications
… that of the original SARS-CoV-2 but can … -resistant mutations in more than 2.2 million
SARS-CoV-2 genomes, we reveal that the occurrence and frequency of vaccine-resistant mutations

Resistance mutations in SARS-CoV-2 omicron variant after tixagevimab-cilgavimab treatment

C Vellas, N Kamar, J Izopet - The Journal of infection, 2022 - ncbi.nlm.nih.gov
… spike-protein mutations that confer resistance to cilgavimab … the risk of transmission of
resistant variants in the community. … -SARS-CoV-2 activity and limit the development of mutations

Naturally occurring mutations of SARS-CoV-2 main protease confer drug resistance to nirmatrelvir

Y Hu, EM Lewandowski, H Tan, X Zhang… - ACS central …, 2023 - ACS Publications
… the alarm of potential drug resistance. To identify potential clinically relevant drug-resistant
mutants, we systematically characterized 102 naturally occurring M pro mutants located at 12 …

Emerging mutations in the SARS-CoV-2 variants and their role in antibody escape to small molecule-based therapeutic resistance

C Chakraborty, M Bhattacharya, AR Sharma - Current Opinion in …, 2022 - Elsevier
mutations in SARS-CoV-2 variants. The small antiviral molecules resistance by the mutations
in … Finally, significant mutations in the variants have been discussed to properly understand …

A SARS-CoV-2 variant with L452R and E484Q neutralization resistance mutations

M Verghese, B Jiang, N Iwai, M Mar… - Journal of Clinical …, 2021 - Am Soc Microbiol
The emergence of SARS-CoV-2 variants that reduce antibody neutralization and vaccine
efficacy is of significant global concern. On 24 March 2021, the Indian SARS-CoV-2 …

Mutations in the SARS-CoV-2 RNA-dependent RNA polymerase confer resistance to remdesivir by distinct mechanisms

LJ Stevens, AJ Pruijssers, HW Lee… - Science translational …, 2022 - science.org
SARS-CoV-2 acquires phenotypic resistance to RDV during passage with GS-441524 …
reported that RDV resistance mutations selected in MHV conferred resistance in SARS-CoV (5). …