[HTML][HTML] SARS-CoV-2 variants, spike mutations and immune escape

WT Harvey, AM Carabelli, B Jackson… - Nature Reviews …, 2021 - nature.com
mutations. In this Review, we summarize the literature on mutations of the SARS-CoV-2 spike
… discuss them in the context of observed mutation frequencies in global sequence datasets. …

Mutations and evolution of the SARS-CoV-2 spike protein

N Magazine, T Zhang, Y Wu, MC McGee, G Veggiani… - Viruses, 2022 - mdpi.com
… by which the common mutations on the spike protein that occur within … mutations within
the context of the SARS-CoV-2 spike protein structure, spike/receptor binding interface, spike/…

[HTML][HTML] The effect of spike mutations on SARS-CoV-2 neutralization

C Rees-Spear, L Muir, SA Griffith, J Heaney, Y Aldon… - Cell reports, 2021 - cell.com
… by infection with the original SARS-CoV-2 virus or current … mutated spike pseudotypes
based on divergence from SARS-CoV and then compare neutralization of the B.1.1.7 spike

Structure and mutations of SARS-CoV-2 spike protein: a focused overview

R Mehra, KP Kepp - ACS Infectious Diseases, 2021 - ACS Publications
… S-protein mutations in the … in mutations of concern, plausibly related to adaptation to the
negative surface potential of human ACE2. We also find indications that the fixated mutations of …

Human SARS CoV‐2 spike protein mutations

L Guruprasad - Proteins: Structure, Function, and Bioinformatics, 2021 - Wiley Online Library
… of mutations in the spike proteins. This study informs us of all the mutations present in the
human SARS-CoV-2 spike … of the mutation sites, distribution of the number of mutations at the …

Structural and functional insights into the spike protein mutations of emerging SARS-CoV-2 variants

D Gupta, P Sharma, M Singh, M Kumar… - Cellular and Molecular …, 2021 - Springer
… The SARS-CoV-2 variants and mutations might be associated with affecting the … variants
of SARS-CoV-2 and the structure–function analysis of key S protein mutations linked with …

[HTML][HTML] D614G spike mutation increases SARS CoV-2 susceptibility to neutralization

D Weissman, MG Alameh, T de Silva, P Collini… - Cell host & …, 2021 - cell.com
… syndrome coronavirus 2 (SARS-CoV-2) spike protein acquired a D614G mutation early in the
… could compromise vaccine efficacy, sera from spike-immunized mice, nonhuman primates, …

Effect of natural mutations of SARS-CoV-2 on spike structure, conformation, and antigenicity

SMC Gobeil, K Janowska, S McDowell, K Mansouri… - Science, 2021 - science.org
… (B) Representation of the trimeric SARS-CoV-2 spike ectodomain in a prefusion conformation
… Each inset corresponds to the spike regions harboring mutations included in this study. (C …

[HTML][HTML] The impact of mutations in SARS-CoV-2 spike on viral infectivity and antigenicity

Q Li, J Wu, J Nie, L Zhang, H Hao, S Liu, C Zhao… - Cell, 2020 - cell.com
… ) as well as mutants at the putative N-linked glycosylation sites in the SARS-CoV-2 S protein.
To achieve these, we generated 106 S mutants reported in the public domain or mutants at …

[HTML][HTML] Spike mutation D614G alters SARS-CoV-2 fitness

JA Plante, Y Liu, J Liu, H Xia, BA Johnson… - Nature, 2021 - nature.com
spike D614G substitution in the USA-WA1/2020 SARS-CoV-… Hamsters infected with
SARS-CoV-2 expressing spike(D614G… evidence showing that the mutation enhances viral loads in …