… the latter recognizing protein receptors for SARS-CoV and MERS-CoV 6,7 . Although these
individual domains have been structurally characterized, the organization of the complete …

… We expressed the SARS-CoV spike protein RBD, residues 306 … We determined the
structure of the ACE2/SARS-CoV/RBD … The SARS-CoV S protein contacts the tip of one lobe of …

… site in SARS-CoV-2 infection is unknown. Here, we report that the cellular protease furin
cleaves the spike protein at the S1/S2 site and that cleavage is essential for S-protein-mediated …

Background The spike (S) protein of SARS-CoV not only mediates receptor-binding but also
induces neutralizing antibodies. We previously identified the receptor-binding domain (RBD…

… binding on the overall spike conformation. To examine this interaction between the SARS-CoV-2
spike protein and its receptor, we mixed the ectodomains of furin-cleaved spike with the …

… -Fc protein could bind to ACE2. We demonstrated that the RBD spike protein alone could
be internalized into SARS-CoV … of N-glycans from the RBD spike protein did not abolish this …

… was activated by SARS-CoV-2, we hypothesized that spike protein could activate … SARS-CoV-2
spike proteins are high quality antigens. To this end, we purified the trimeric spike protein …

… Antibodies that specifically recognize the SARS-CoV spike and nucleocapsid proteins may
… SARS-CoV spike protein and polyclonal antibodies against SARS-CoV nucleocapsid protein …

… of virus-encoded fusion proteins from a primed, metastable … protein for CoV is its spike (S)
protein that decorates the virion surface as an extensive crown (hence, “corona”). The protein …

… have monitored the evolution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
with particular focus on the spike protein. An early variant with an aspartic acid (D) to …