SARS-CoV-2 spike protein: flexibility as a new target for fighting infection

CL Pierri - Signal Transduction and Targeted Therapy, 2020 - nature.com
… the most performing neutralizing antibodies active against the homologous SARS-CoV
spike proteins were able to bind efficiently the spike protein when the RBD subunits in the pre-…

[HTML][HTML] Spike proteins of SARS-CoV and SARS-CoV-2 utilize different mechanisms to bind with human ACE2

Y Xie, CB Karki, D Du, H Li, J Wang… - Frontiers in molecular …, 2020 - frontiersin.org
… demonstrate that SARS-CoV and SARS-CoV-2 S proteins are … between SARS-CoV S
protein and SARS-CoV-2 S protein. … ACE2 and S proteins for both SARS-CoV and SARS-CoV-2. …

… of novel neutralizing epitopes in the receptor-binding domain of SARS-CoV spike protein: revealing the critical antigenic determinants in inactivated SARS-CoV …

Y He, J Li, L Du, X Yan, G Hu, Y Zhou, S Jiang - Vaccine, 2006 - Elsevier
… coronaviruses, SARS-CoV is … proteins and major structural proteins consisting of spike (S),
nucleocapsid (N), membrane (M), and small envelope protein (E), and several small proteins

Functional importance of the D614G mutation in the SARS-CoV-2 spike protein

CB Jackson, L Zhang, M Farzan, H Choe - Biochemical and Biophysical …, 2021 - Elsevier
… cells is less efficient than that mediated by SARS-CoV-1 S and is more highly dependent
on … of SARS-CoV-2 compared to SARS-CoV-1 spike trimers, although the RBD of SARS-CoV-2 …

The receptor-binding domain of the viral spike protein is an immunodominant and highly specific target of antibodies in SARS-CoV-2 patients

L Premkumar, B Segovia-Chumbez, R Jadi… - Science …, 2020 - science.org
… structure coordinates of the coronavirus spike proteins from the PDB to define the boundaries
for the design of RBD expression constructs: SARS-CoV-2 (6VSB), SARS-CoV-1 (6CRV), …

[HTML][HTML] Structural and functional properties of SARS-CoV-2 spike protein: potential antivirus drug development for COVID-19

Y Huang, C Yang, X Xu, W Xu, S Liu - Acta Pharmacologica Sinica, 2020 - nature.com
… , the S protein of SARS-CoV-2 is similar to that of SARS-CoV, … S protein cleavage of both
SARS-CoV-2 and SARS-CoV. … The coronavirus spike protein is a class I virus fusion protein: …

Structural and antigenic variations in the spike protein of emerging SARS-CoV-2 variants

A Mittal, A Khattri, V Verma - PLoS Pathogens, 2022 - journals.plos.org
spike protein that confer immune evasion. Antibodies are key components of the human
immune system’s response to SARS-CoV-2, and the spike protein is … on the spike protein, which …

Up-regulation of IL-6 and TNF-α induced by SARS-coronavirus spike protein in murine macrophages via NF-κB pathway

W Wang, L Ye, L Ye, B Li, B Gao, Y Zeng, L Kong… - Virus research, 2007 - Elsevier
… that SARS-CoV spike protein may play an important role in the pathogenesis of SARS, …
Then, we had the hypothesis that the spike protein plays an important role in the production of …

A thermostable, closed SARS-CoV-2 spike protein trimer

X Xiong, K Qu, KA Ciazynska, M Hosmillo… - Nature structural & …, 2020 - nature.com
… The spike (S) protein of SARS-CoV-2 mediates receptor … S-protein derivatives are components
of vaccine candidates … into the biology and immunology of SARS-CoV-2. Here we have …

An infectivity-enhancing site on the SARS-CoV-2 spike protein targeted by antibodies

Y Liu, WT Soh, J Kishikawa, M Hirose, EE Nakayama… - Cell, 2021 - cell.com
spike protein domains are largely unknown. Here, we screened a series of anti-spike monoclonal
antibodies from coronavirus … of the spike protein to ACE2 and infectivity of SARS-CoV-2…