Binding of the SARS-CoV-2 spike protein to glycans

W Hao, B Ma, Z Li, X Wang, X Gao, Y Li, B Qin… - Science Bulletin, 2021 - Elsevier
… and spike (S) proteins of SARS-CoV-2 and SARS-CoV, MERS-CoV to heparan sulfate (HS)
and sialic acid-containing glycans. Our results revealed that all the tested protein molecules …

SARS-CoV-2 spike protein: a key target for eliciting persistent neutralizing antibodies

Y Yang, L Du - Signal transduction and targeted therapy, 2021 - nature.com
SARS-CoV-2 spike (S) protein is a key target for eliciting neutralizing antibodies. a Schematic
structures of SARS-CoV-2 virion and its S protein. M, … b Mode of action of SARS-CoV-2 S-…

N501Y mutation of spike protein in SARS-CoV-2 strengthens its binding to receptor ACE2

F Tian, B Tong, L Sun, S Shi, B Zheng, Z Wang, X Dong… - elife, 2021 - elifesciences.org
… Envelope-anchored spike proteins are capable of mediating coronavirus entry into host cells
… The coronavirus spike protein, a class I fusion protein, is synthesized as a precursor single …

N-and O-glycosylation of the SARS-CoV-2 spike protein

M Sanda, L Morrison, R Goldman - Analytical chemistry, 2021 - ACS Publications
… of the spike protein at R682, a polybasic cleavage site that differs from … SARS-CoV spike
protein of 2002. By analysis of the protein produced in HEK293 cells, we observe that the spike

Characterizations of SARS-CoV-2 mutational profile, spike protein stability and viral transmission

S Laha, J Chakraborty, S Das, SK Manna… - Infection, genetics and …, 2020 - Elsevier
… We have identified frequently mutated residues by aligning ~660 SARS-CoV-… protein structure
stability of spike glycoprotein and their possible functional consequences in other proteins. …

A hexapeptide of the receptor-binding domain of SARS corona virus spike protein blocks viral entry into host cells via the human receptor ACE2

AW Struck, M Axmann, S Pfefferle, C Drosten, B Meyer - Antiviral research, 2012 - Elsevier
… by SARS coronavirus (SARS-CoV) is blocked by hexapeptide Tyr-Lys-Tyr-Arg-Tyr-Leu. The
peptide also inhibits proliferation of coronavirus … ) of the spike protein of SARS-CoV. Peptide …

D614G mutation of SARS-CoV-2 spike protein enhances viral infectivity

J Hu, CL He, QZ Gao, GJ Zhang, XX Cao, QX Long… - BioRxiv, 2020 - biorxiv.org
… The S protein of SARS-CoV-2, which contains 1,273 amino acids, forms a trimeric spike on …
We analyzed the SARS-CoV-2 S protein amino acid sequence from viral genomic sequences …

Antibody cocktail to SARS-CoV-2 spike protein prevents rapid mutational escape seen with individual antibodies

A Baum, BO Fulton, E Wloga, R Copin, KE Pascal… - Science, 2020 - science.org
… four antibodies to the spike protein that potently neutralize SARS-CoV-2, individually as
well … against spike variants that have arisen in the human population. However, novel spike

Could SARS-CoV-2 spike protein be responsible for long-COVID syndrome?

TC Theoharides - Molecular Neurobiology, 2022 - Springer
SARS-CoV-2 infects cells via its spike protein binding to its … the spike protein, or administer
recombinant spike protein, … , while others showed that the spike protein could damage the …

[HTML][HTML] The D614G mutation in the SARS-CoV-2 spike protein reduces S1 shedding and increases infectivity

L Zhang, CB Jackson, H Mou, A Ojha, ES Rangarajan… - BioRxiv, 2020 - ncbi.nlm.nih.gov
… Belouzard S., Chu VC & Whittaker GR Activation of the SARS coronavirus spike protein via
sequential proteolytic cleavage at two distinct sites. Proceedings of the National Academy of …