The spike protein of SARS-CoV—a target for vaccine and therapeutic development

L Du, Y He, Y Zhou, S Liu, BJ Zheng… - Nature Reviews …, 2009 - nature.com
… on the spike (S) protein of severe acute respiratory syndrome-coronavirus (SARS-CoV) as a
… for the development of vaccines and therapeutics for the prevention and treatment of SARS. …

Domains and functions of spike protein in Sars-Cov-2 in the context of vaccine design

X Xia - Viruses, 2021 - mdpi.com
SARS-CoV-2 uses its trimeric spike protein for binding to … three separate S protein cleavage
events to prime the SARS-2-… These processes involve different domains of the S protein

Structure of SARS-CoV-2 spike protein

J Zhang, T Xiao, Y Cai, B Chen - Current opinion in virology, 2021 - Elsevier
… the structural biology of SARS-CoV-2 S protein has been made … of the structure of the
SARS-CoV-2 S protein and discuss the … the structure of the SARS-CoV-2 S protein and discuss the …

Dynamics of the ACE2–SARS-CoV-2/SARS-CoV spike protein interface reveal unique mechanisms

A Ali, R Vijayan - Scientific reports, 2020 - nature.com
… of the spike (S) protein of SARS-CoV-2 and SARS-CoV bound to … Our results indicate that
SARS-CoV-2 and SARS-CoV … the residues of SARS-CoV-2 and SARS-CoV that consistently …

Composition and divergence of coronavirus spike proteins and host ACE2 receptors predict potential intermediate hosts of SARSCoV‐2

Z Liu, X Xiao, X Wei, J Li, J Yang, H Tan… - Journal of medical …, 2020 - Wiley Online Library
… It is noteworthy that SARS-CoV was the most widely distributed coronavirus in … SARS-CoV-2
reads and found that the spike protein sequence was present in pangolin SARS-like CoV (…

[HTML][HTML] Spike proteins of SARS-CoV and SARS-CoV-2 utilize different mechanisms to bind with human ACE2

Y Xie, CB Karki, D Du, H Li, J Wang… - Frontiers in molecular …, 2020 - frontiersin.org
… demonstrate that SARS-CoV and SARS-CoV-2 S proteins are … between SARS-CoV S
protein and SARS-CoV-2 S protein. … ACE2 and S proteins for both SARS-CoV and SARS-CoV-2. …

Cell entry mechanisms of SARS-CoV-2

J Shang, Y Wan, C Luo, G Ye, Q Geng… - Proceedings of the …, 2020 - National Acad Sciences
… Here we investigate the receptor binding and protease activations of SARS-CoV-2 spike, using
SARS-CoV spike as … Using protein pull-down assay, the current study showed that SARS-…

Activation of the SARS coronavirus spike protein via sequential proteolytic cleavage at two distinct sites

S Belouzard, VC Chu… - Proceedings of the …, 2009 - National Acad Sciences
… To investigate the possibility that additional, possibly cryptic, cleavage sites exist within the
coronavirus spike protein, we examined a comprehensive selection of spike proteins from …

[HTML][HTML] Silencing SARS-CoV Spike protein expression in cultured cells by RNA interference

Y Zhang, T Li, L Fu, C Yu, Y Li, X Xu, Y Wang, H Ning… - FEBS letters, 2004 - Elsevier
… of Spike protein from SARS-CoV-infected cells or tissues. In this report we used the
recombinant Spike protein cDNA from the SARS-CoV genome and expressed the protein in 293T …

Inhibition of the interaction between the SARS-CoV spike protein and its cellular receptor by anti-histo-blood group antibodies

P Guillon, M Clément, V Sébille, JG Rivain… - …, 2008 - academic.oup.com
… Severe acute respiratory syndrome coronavirus (SARS-CoV) … The heavily glycosylated
SARS-CoV spike (S) protein binds … system could block the S protein and angiotensin-converting …