Structure of the SARS-CoV-2 spike receptor-binding domain bound to the ACE2 receptor

J Lan, J Ge, J Yu, S Shan, H Zhou, S Fan, Q Zhang… - nature, 2020 - nature.com
… of the receptor-binding domain (RBD) of the spike protein of SARS-CoV-2 bound to the cell
receptor … ACE2-binding mode of the SARS-CoV-2 RBD is nearly identical to that of the SARS-…

Structure of SARS coronavirus spike receptor-binding domain complexed with receptor

F Li, W Li, M Farzan, SC Harrison - Science, 2005 - science.org
spike protein (S) of SARS coronavirus (SARS-CoV) attaches the virus to its cellular receptor,
… (A) Domain structure of the SARS-CoV spike protein. The boundaries of the RBD were …

Receptor binding and priming of the spike protein of SARS-CoV-2 for membrane fusion

DJ Benton, AG Wrobel, P Xu, C Roustan, SR Martin… - Nature, 2020 - nature.com
… binding on the overall spike conformation. To examine this interaction between the SARS-CoV-2
spike protein and its receptor, we mixed the ectodomains of furin-cleaved spike with the …

The spike protein of SARS-CoV—a target for vaccine and therapeutic development

L Du, Y He, Y Zhou, S Liu, BJ Zheng… - Nature Reviews …, 2009 - nature.com
… caused by a novel coronavirus, SARS-coronavirus (SARS-CoV). The SARS-CoV spike (S)
protein is composed of two subunits; the S1 subunit contains a receptor-binding domain that …

Differences and similarities between SARS-CoV and SARS-CoV-2: spike receptor-binding domain recognition and host cell infection with support of cellular serine …

GA Rossi, O Sacco, E Mancino, L Cristiani, F Midulla - Infection, 2020 - Springer
… , SARSCoV-2 infection appears to be much more contagious. Moreover, many SARS-CoV-2 …
a more effective SARS-CoV-2 immune surveillance evasion than SARS-CoV. This paper …

Cryo-EM structures of MERS-CoV and SARS-CoV spike glycoproteins reveal the dynamic receptor binding domains

Y Yuan, D Cao, Y Zhang, J Ma, J Qi, Q Wang… - Nature …, 2017 - nature.com
CoV and SARS-CoV S trimers have flexible RBD, and then we further constructed the receptor
binding models for the MERS-CoV or SARS-CoV … the RBD-receptor complex structures …

[HTML][HTML] Structural basis of receptor recognition by SARS-CoV-2

J Shang, G Ye, K Shi, Y Wan, C Luo, H Aihara, Q Geng… - Nature, 2020 - nature.com
… A key to tackling this pandemic is to understand the receptorSARS-CoV-2 and SARS-CoV
recognize the same receptor—… receptor-binding domain (RBD) of the spike protein of SARS-…

Inhibition of the interaction between the SARS-CoV spike protein and its cellular receptor by anti-histo-blood group antibodies

P Guillon, M Clément, V Sébille, JG Rivain… - …, 2008 - academic.oup.com
… Severe acute respiratory syndrome coronavirus (SARS-CoV) is a highly … SARS-CoV spike
(S) protein binds to angiotensin-converting enzyme 2 which serves as a cellular receptor. …

The receptor-binding domain of the viral spike protein is an immunodominant and highly specific target of antibodies in SARS-CoV-2 patients

L Premkumar, B Segovia-Chumbez, R Jadi… - Science …, 2020 - science.org
… with SARS-CoV-1 or SARS-CoV-2 spike proteins to assess … SARS-CoV-2 spike protein
had antibodies that bound well to the RBD of SARS-CoV-2 and poorly to the RBDs of SARS-CoV-…

Composition and divergence of coronavirus spike proteins and host ACE2 receptors predict potential intermediate hosts of SARSCoV‐2

Z Liu, X Xiao, X Wei, J Li, J Yang, H Tan… - Journal of medical …, 2020 - Wiley Online Library
… This study focuses on comparisons of the spike sequences between SARS-CoV-2 with
SARS-CoV, bat SARS-like CoV, and other coronaviruses, which are helpful for evolutionary …