[HTML][HTML] Virus-receptor interactions of glycosylated SARS-CoV-2 spike and human ACE2 receptor

P Zhao, JL Praissman, OC Grant, Y Cai, T Xiao… - Cell host & …, 2020 - cell.com
SARS-CoV-2 betacoronavirus uses its highly glycosylated trimeric Spike protein to bind to
the cell surface receptor … for a recombinant trimer Spike mimetic immunogen and for a soluble …

Persistence and decay of human antibody responses to the receptor binding domain of SARS-CoV-2 spike protein in COVID-19 patients

AS Iyer, FK Jones, A Nodoushani, M Kelly… - Science …, 2020 - science.org
… antibody isotype profile to the receptor binding domain (RBD) of the spike (S) protein of
SARS-CoV-2 in a longitudinal cohort of North American patients infected with SARS-CoV-2, most …

Potent binding of 2019 novel coronavirus spike protein by a SARS coronavirus-specific human monoclonal antibody

X Tian, C Li, A Huang, S Xia, S Lu, Z Shi… - Emerging microbes & …, 2020 - Taylor & Francis
… We also predicted the conformations of 2019-nCoV RBD and its complex with the putative
receptor, human ACE2. Comparison of the interaction between the complex of ACE2 [Citation…

[HTML][HTML] Recombinant receptor-binding domain of SARS-CoV spike protein expressed in mammalian, insect and E. coli cells elicits potent neutralizing antibody and …

L Du, G Zhao, CCS Chan, S Sun, M Chen, Z Liu, H Guo… - Virology, 2009 - Elsevier
… prevent a future SARS epidemic. In this study, we expressed the recombinant receptor-binding …
coli, respectively, and compared their immunogenicity and protection against SARS-CoV

Interaction of the spike protein RBD from SARS-CoV-2 with ACE2: Similarity with SARS-CoV, hot-spot analysis and effect of the receptor polymorphism

H Othman, Z Bouslama, JT Brandenburg… - Biochemical and …, 2020 - Elsevier
… (ACE2) is more likely to be the cell receptor through which the virus invades the host cell. In
… of the viral spike Receptor Binding Domain (RBD) from different coronavirus isolates with …

[HTML][HTML] The spike of concern—the novel variants of SARS-CoV-2

A Winger, T Caspari - Viruses, 2021 - mdpi.com
… in the viral spike protein (base change: A23403G, reference sequence: EPI_ISL_450201)
[4]. Each SARS-CoV-2 virus carries approximately 90 homo-trimeric spike receptors in its …

The mechanism and consequences of SARS-CoV-2 spike-mediated fusion and syncytia formation

MM Rajah, A Bernier, J Buchrieser… - Journal of molecular …, 2022 - Elsevier
SARS-CoV-2 induces syncytia when the viral spike (S) protein on the surface of an infected
cell interacts with receptors on … SARS-CoV-2 variants of concern possess several mutations …

[HTML][HTML] COVID-19 survival associates with the immunoglobulin response to the SARS-CoV-2 spike receptor binding domain

M Secchi, E Bazzigaluppi, C Brigatti… - The Journal of …, 2020 - Am Soc Clin Investig
… to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in populations, and …
spike receptor binding domain (RBD), S1+S2, nucleocapsid, and ORF6 to ORF10 of SARS-CoV-2…

[HTML][HTML] SARS-CoV-2 spike protein: flexibility as a new target for fighting infection

CL Pierri - Signal Transduction and Targeted Therapy, 2020 - nature.com
… protein of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is crucial for
… the SARS-CoV-2 spike receptor-binding domain (RBD) and the human ACE2 receptor. Since …

[HTML][HTML] Conformational reorganization of the SARS coronavirus spike following receptor binding: implications for membrane fusion

DR Beniac, SL deVarennes, A Andonov, R He… - PloS one, 2007 - journals.plos.org
… changes in the SARS spike that accompanied receptor-binding, and to precisely localize
the receptor binding domains (which are only 14% of the total mass of the spike) within the …