[HTML][HTML] SARS-CoV-2 variants, spike mutations and immune escape

WT Harvey, AM Carabelli, B Jackson… - Nature Reviews …, 2021 - nature.com
… of mutations, in the context of ‘variants of concern’, that impact virus … of some SARS-CoV-2
variants by postvaccination serum; … on mutations of the SARS-CoV-2 spike protein, the primary …

The spike of concern—the novel variants of SARS-CoV-2

A Winger, T Caspari - Viruses, 2021 - mdpi.com
… The D614G mutation is the hallmark of all variants, as it promotes viral spread by increasing
… the new SARS-CoV-2 variants is the co-evolution of mutation clusters in Spike that advance …

[HTML][HTML] Structural and functional analysis of the D614G SARS-CoV-2 spike protein variant

L Yurkovetskiy, X Wang, KE Pascal, C Tomkins-Tinch… - Cell, 2020 - cell.com
The SARS-CoV-2 spike (S) protein variant D614G supplanted the ancestral virus worldwide,
reaching near fixation in a matter of months. Here we show that D614G was more infectious …

[HTML][HTML] The effect of spike mutations on SARS-CoV-2 neutralization

C Rees-Spear, L Muir, SA Griffith, J Heaney, Y Aldon… - Cell reports, 2021 - cell.com
… Because new SARS-CoV-2 variants are emerging rapidly, as exemplified by the B.1.1.7,
B.1.351, and P.1 lineages, it is critical to understand whether antibody responses induced by …

[HTML][HTML] Understanding variants of SARS-CoV-2

T Burki - Lancet (London, England), 2021 - ncbi.nlm.nih.gov
All viruses mutate. But three variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
have raised particular concerns. On Jan 21, 2021, the UK New and Emerging …

Structural and antigenic variations in the spike protein of emerging SARS-CoV-2 variants

A Mittal, A Khattri, V Verma - PLoS Pathogens, 2022 - journals.plos.org
… naturally occurring SARS-CoV-2 variants including the Delta and Omicron variants that armor
… and therapeutically relevant antibodies binding with a focus on the SARS-CoV-2 variants. …

Structural and functional insights into the spike protein mutations of emerging SARS-CoV-2 variants

D Gupta, P Sharma, M Singh, M Kumar… - Cellular and Molecular …, 2021 - Springer
SARS-CoV-2, Spike (S) protein binds to host cells by … The SARS-CoV-2 variants and mutations
might be associated … This review focuses on the current circulating variants of SARS-CoV-…

Genetic variants of SARS-CoV-2—what do they mean?

AS Lauring, EB Hodcroft - Jama, 2021 - jamanetwork.com
… The 501Y spike variants are predicted to have a higher affinity for … spike variants. Regardless
of why the mutations were selected, it is reasonable to expect that many mutations in spike

SARS-CoV-2 vaccines based on the spike glycoprotein and implications of new viral variants

D Martínez-Flores, J Zepeda-Cervantes… - Frontiers in …, 2021 - frontiersin.org
… vaccines against emerging SARS-CoV-2 variants. … SARS-CoV-2 variants in countries with
limited access to vaccines, the redesign SARS-CoV-2 vaccines based on these new variants is …

The biological and clinical significance of emerging SARS-CoV-2 variants

K Tao, PL Tzou, J Nouhin, RK Gupta… - Nature Reviews …, 2021 - nature.com
… -2 evolution, the structure and function of the SARS-CoV-2 spike protein and the laboratory
methods used to characterize spike variants. We then describe the biological properties and …