Structural insights in cell-type specific evolution of intra-host diversity by SARS-CoV-2

K Gupta, C Toelzer, MK Williamson… - Nature …, 2022 - nature.com
… To understand the structural impact of the deletion of the furin cleavage site on SARS-CoV-2
S architecture, we produced the BriSΔ spike by MultiBac/insect cell expression 23 . We …

Structural insight into the SARS-CoV-2 nucleocapsid protein C-terminal domain reveals a novel recognition mechanism for viral transcriptional regulatory sequences

M Yang, S He, X Chen, Z Huang, Z Zhou, Z Zhou… - Frontiers in …, 2021 - frontiersin.org
… To determine the precise structural information of the novel coronavirus SARS-CoV-2 N-CTD,
we solved the N-CTD structure at a resolution of 2.0 Å with X-ray crystallography. The final …

Structural insights of key enzymes into therapeutic intervention against SARS-CoV-2

M Shahid, S Shahzad-ul-Hussan - Journal of Structural Biology, 2021 - Elsevier
… In this review we recapitulated the structural features of the key catalytic proteins involved
in the SARS-CoV-2 pathogenesis, their main catalytic sites and other structural regions …

Structural insights into SARS-CoV-2 spike protein and its natural mutants found in Mexican population

Y Sixto-López, J Correa-Basurto, M Bello… - Scientific Reports, 2021 - nature.com
… emerged coronavirus responsible for coronavirus disease … described three lineages of
SARS-CoV-2 circulating worldwide… could affect the structural behavior of S protein of SARS-CoV-2…

The SARS-CoV-2 spike glycoprotein as a drug and vaccine target: structural insights into its complexes with ACE2 and antibodies

AC Papageorgiou, I Mohsin - Cells, 2020 - mdpi.com
… of SARS-CoV-2 and its interactions with ACE2 and antibodies. Structural information of
SARS-CoV… key input for the development of therapies and vaccines against the new coronavirus. …

Biochemical and structural insights into the mechanisms of SARS coronavirus RNA ribose 2′-O-methylation by nsp16/nsp10 protein complex

Y Chen, C Su, M Ke, X Jin, L Xu, Z Zhang, A Wu… - PLoS …, 2011 - journals.plos.org
… for SARS-CoV is that nsp16 requires non-structuralSARS-CoV 2′-O-MTase and the crystal
structure of nsp16/nsp10 complex bound with methyl donor SAM. We found that SARS-CoV

Structural insights into the binding of SARS-CoV-2, SARS-CoV, and hCoV-NL63 spike receptor-binding domain to horse ACE2

J Lan, P Chen, W Liu, W Ren, L Zhang, Q Ding… - Structure, 2022 - cell.com
… Our results reveal the molecular basis of eACE2 binding to the RBDs of SARS-CoV,
SARS-CoV-2, and hCoV-NL63, which provides insights into the potential animal transmission of …

Structural insights of a highly potent pan-neutralizing SARS-CoV-2 human monoclonal antibody

JL Torres, G Ozorowski, E Andreano… - Proceedings of the …, 2022 - National Acad Sciences
As the coronavirus disease 2019 (COVID-19) pandemic continues, there is a strong need
for highly potent monoclonal antibodies (mAbs) that are resistant against severe acute …

SARS-CoV CH. 1.1 variant: genomic and structural insight

L Bazzani, E Imperia, F Scarpa, D Sanna… - Infectious Disease …, 2023 - mdpi.com
… We provide a preliminary understanding of the global distribution of this emerging SARS-CoV-2
variant by combining genomic data with structural molecular modeling. In addition, we …

Structural and molecular perspectives of SARS-CoV-2

S Kumar, SK Saxena - Methods, 2021 - Elsevier
… Prominently, comprehensive analysis of structural insights into the crucial SARS-CoV-2 …
and structural perspective of SARS-CoV-2 including mechanistic insights in its replication. …