[HTML][HTML] Total escape of SARS-CoV-2 from dual monoclonal antibody therapy in an immunocompromised patient

L Jaki, S Weigang, L Kern, S Kramme… - Nature …, 2023 - nature.com
… Here, we describe the efficient escape of SARS-CoV-2 from the REGN-COV dual mAb therapy
in a severely immunocompromised individual. During the prolonged chronic infection and …

The global epidemic of SARSCoV‐2 variants and their mutational immune escape

D Tian, YH Sun, JM Zhou, Q Ye - Journal of medical virology, 2022 - Wiley Online Library
… These SARS-CoV-2 variants … escape of different SARS-CoV-2 variants. We hope to provide
scientific reference for the monitoring, prevention, and control measures of new SARS-CoV-2 …

[PDF][PDF] Emergence of immune escape at dominant SARS-CoV-2 killer T cell epitope

G Dolton, C Rius, MS Hasan, A Wall, B Szomolay… - Cell, 2022 - cell.com
… We reasoned that if SARS-CoV-2 were to exhibit escape from CD8 T cells, then this would
… We therefore focused our attention on residues 269–277 of the SARSCoV-2 Spike protein …

[HTML][HTML] Mapping mutations to the SARS-CoV-2 RBD that escape binding by different classes of antibodies

AJ Greaney, TN Starr, CO Barnes, Y Weisblum… - Nature …, 2021 - nature.com
SARS-CoV-2 has already acquired mutations that reduce binding by each antibody class,
we compared the total escape … at the site among sequenced SARS-CoV-2 isolates in GISAID …

[HTML][HTML] Antibody escape and global spread of SARS-CoV-2 lineage A. 27

T Kaleta, L Kern, SL Hong, M Hölzer, G Kochs… - Nature …, 2022 - nature.com
… inferred origin and phenotypic characteristics of SARS-CoV-2 lineage A.… Our data demonstrate
that A.27 can partially escape the … escape variants that threaten global vaccination efforts. …

[HTML][HTML] SARS-CoV-2 variant biology: immune escape, transmission and fitness

AM Carabelli, TP Peacock, LG Thorne… - Nature Reviews …, 2023 - nature.com
… in SARS-CoV-2 immunity, the potential exists for selective pressure to lead to T cell escape,
although the extent to which SARS-CoVSARS-CoV-2 genome, the footprints of T cell escape

[PDF][PDF] Population impact of SARS-CoV-2 variants with enhanced transmissibility and/or partial immune escape

M Bushman, R Kahn, BP Taylor, M Lipsitch… - Cell, 2021 - cell.com
… —transmissibility and immune escape—on the population dynamics of emerging variants
and the course of SARSCoV-2 epidemics. In order to disentangle the effects of these …

[HTML][HTML] SARS-CoV-2 RBD antibodies that maximize breadth and resistance to escape

TN Starr, N Czudnochowski, Z Liu, F Zatta, YJ Park… - Nature, 2021 - nature.com
escape, breadth and potency across a panel of SARS-CoV-2 … a corresponding resistance
to SARS-CoV-2 escape. One of … breadth and are readily escaped by mutations despite high …

[HTML][HTML] Multiple SARS-CoV-2 variants escape neutralization by vaccine-induced humoral immunity

WF Garcia-Beltran, EC Lam, KS Denis, AD Nitido… - Cell, 2021 - cell.com
… 10 globally circulating strains of SARS-CoV-2. Five of the 10 … SARS-CoV and bat-derived
WIV1-CoV, suggesting that a relatively small number of mutations can mediate potent escape

[HTML][HTML] Omicron escapes the majority of existing SARS-CoV-2 neutralizing antibodies

Y Cao, J Wang, F Jian, T Xiao, W Song, A Yisimayi… - Nature, 2022 - nature.com
… were performed on the basis of the N×M escape score matrix, in which N is the number of …
sites on the SARS-CoV-2 RBD. Each entry of the matrix A nm refers to the total escape score of …