SARS-CoV-2 spike protein promotes IL-6 trans-signaling by activation of angiotensin II receptor signaling in epithelial cells

T Patra, K Meyer, L Geerling, TS Isbell, DF Hoft… - PLoS …, 2020 - journals.plos.org
… suggest the potential for IL-6 trans-signaling during SARS-CoV-2 infection of epithelial cells.
… that SARS-CoV-2 infection in pulmonary epithelial cells induces IL-6 trans-signaling for …

Dysregulation of cell signaling by SARS-CoV-2

RK Suryawanshi, R Koganti, A Agelidis, CD Patil… - Trends in …, 2021 - cell.com
… with host signaling pathways. We also address the functional changes in SARS-CoV-2
proteins, relative to SARS-CoV. Our comprehensive assessment of host signaling in SARS-CoV-…

Unpuzzling COVID-19: tissue-related signaling pathways associated with SARS-CoV-2 infection and transmission

DS Battagello, G Dragunas, MO Klein… - Clinical …, 2020 - portlandpress.com
… In this review, we explore the current knowledge of SARS-CoV-2 infection and transmission,
focusing on the main aspects of cellular signaling pathways that are impacted by SARS-CoV

Role of toll‐like receptors in modulation of cytokine storm signaling in SARSCoV‐2‐induced COVID‐19

M Manik, RK Singh - Journal of medical virology, 2022 - Wiley Online Library
… prone to the SARS-COV infection and suffered … SARS-COV infection, but the absence of
TRIF-mediated adaptor molecules (TRAM) signaling renders the mice susceptible to SARS-COV

A Hybrid Soluble gp130/Spike-Nanobody Fusion Protein Simultaneously Blocks Interleukin-6 trans-Signaling and Cellular Infection with SARS-CoV-2

J Ettich, J Werner, HT Weitz, E Mueller… - Journal of …, 2022 - Am Soc Microbiol
… as well as the spike protein of SARS-CoV-2, as shown by surface plasmon … trans-signaling-induced
proliferation and STAT3 phosphorylation in Ba/F3-gp130 cells as well as SARS-CoV-…

[HTML][HTML] SARS-CoV-2 and COVID-19: Is interleukin-6 (IL-6) the 'culprit lesion'of ARDS onset? What is there besides Tocilizumab? SGP130Fc

G Magro - Cytokine: X, 2020 - Elsevier
… This is another evidence of the pro-inflammatory role of the trans-signaling pathway and it
could … response mediated by IL-6, similarly to what is happening with SARS-CoV-2 infection. …

The ORF6, ORF8 and nucleocapsid proteins of SARS-CoV-2 inhibit type I interferon signaling pathway

JY Li, CH Liao, Q Wang, YJ Tan, R Luo, Y Qiu, XY Ge - Virus research, 2020 - Elsevier
… conducted on SARS-CoV-2. In this study, we screened the viral proteins of SARS-CoV-2 and
… were potential inhibitors of type I interferon signaling pathway, a key component for antiviral …

DC/L-SIGN recognition of spike glycoprotein promotes SARS-CoV-2 trans-infection and can be inhibited by a glycomimetic antagonist

M Thépaut, J Luczkowiak, C Vivès, N Labiod… - PLoS …, 2021 - journals.plos.org
… Indeed, S proteins from both SARS-CoV-1 and SARS-CoV-2 have identical … transmission
rates [24]. We posit that the enhanced transmission rate of SARS-CoV-2 relative to SARS-CoV-…

The roles of signaling pathways in SARS-CoV-2 infection; lessons learned from SARS-CoV and MERS-CoV

N Hemmat, Z Asadzadeh, NK Ahangar… - Archives of …, 2021 - Springer
… effects of these inflammatory cellular signaling pathways, and these might be … signaling
pathways that are associated with coronavirus infection, particularly SARS-CoV and MERS-CoV

Computationally predicted SARS-COV-2 encoded microRNAs target NFKB, JAK/STAT and TGFB signaling pathways

MN Aydemir, HB Aydemir, EM Korkmaz, M Budak… - Gene Reports, 2021 - Elsevier
… Our target gene analysis showed that the identified 40 SARS-CoV-2 miRNAs target genes
in signaling pathways including NFKB, JAK/STAT and TGFB signaling pathways. All of these …