Molecular determinants and mechanism for antibody cocktail preventing SARS-CoV-2 escape

Z Ku, X Xie, E Davidson, X Ye, H Su… - Nature …, 2021 - nature.com
… it doesn’t escape from the cocktail due to stronger mutational … shared between SARS-CoV-2
and SARS-CoV for antibody CoV2… of antibody cocktails as candidates for treating COVID-19. …

Antibody cocktail to SARS-CoV-2 spike protein prevents rapid mutational escape seen with individual antibodies

A Baum, BO Fulton, E Wloga, R Copin, KE Pascal… - Science, 2020 - science.org
… therapy may provide a powerful way to minimize mutational escape by SARS-CoV-2; in
particular, our studies point to the potential value of antibody cocktails in which two antibodies

Antibody cocktail effective against variants of SARS-CoV-2

KH Liang, PY Chiang, SH Ko, YC Chou, RM Lu… - Journal of Biomedical …, 2021 - Springer
… We next tested the therapeutic effects of the antibody cocktail administered after SARS-CoV-2
infection in the hamster model (Fig. 4). We treated hamsters with RBD-chAb-15 or -28 …

Genetic and structural basis for SARS-CoV-2 variant neutralization by a two-antibody cocktail

J Dong, SJ Zost, AJ Greaney, TN Starr… - Nature …, 2021 - nature.com
… strong neutralizing activity against SARS-CoV-2 and variants of concern … antibody features
enable recognition of the SARS-CoV-2 spike RBD and demonstrate the utility of the cocktail

Studies in humanized mice and convalescent humans yield a SARS-CoV-2 antibody cocktail

J Hansen, A Baum, KE Pascal, V Russo, S Giordano… - Science, 2020 - science.org
… using both mice and humans to generate antibodies against the spike protein of severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The ability to derive antibodies using …

Development and structural basis of a two-MAb cocktail for treating SARS-CoV-2 infections

C Zhang, Y Wang, Y Zhu, C Liu, C Gu, S Xu… - Nature …, 2021 - nature.com
… a humanized anti-SARS-CoV-2 antibody cocktail with therapeutic potential. … antibody
cocktail. These structural information enhances our understanding of anti-SARS-CoV-2 antibody-…

Genetic and structural basis for recognition of SARS-CoV-2 spike protein by a two-antibody cocktail

J Dong, SJ Zost, AJ Greaney, TN Starr, AS Dingens… - BioRxiv, 2021 - biorxiv.org
two additional antibodies of this clonotype from our own panel of anti-SARS-CoV-2 antibodies
As expected, given that these antibodies are members of a shared genetic clonotype, the …

Structure-based development of human antibody cocktails against SARS-CoV-2

N Wang, Y Sun, R Feng, Y Wang, Y Guo, L Zhang… - Cell research, 2021 - nature.com
… 10 against SARS-CoV-2 and SARS-CoV has a potential to constitute the fourth
component for our cocktails (Fig. 1g), conferring synergy in protective efficacy against pan-SARS-CoVs …

REGN-COV2, a neutralizing antibody cocktail, in outpatients with Covid-19

DM Weinreich, S Sivapalasingam… - … England Journal of …, 2021 - Mass Medical Soc
… investigating REGN-COV2, an antibody cocktail containing two SARS-CoV-2–neutralizing …
with Ebola virus. Our analysis suggests that an antibody cocktail against SARS-CoV-2 can …

Structure-based development of three-and four-antibody cocktails against SARS-CoV-2 via multiple mechanisms

Y Sun, L Wang, R Feng, N Wang, Y Wang, D Zhu… - Cell research, 2021 - nature.com
… of the potential three- and four-antibody cocktails, we performed cryo-EM analysis of the
SARS-CoV-2 S trimer in complex with two sets of multiple-antibody cocktails (FC05–H014–P17; …