… therapy may provide a powerful way to minimize mutational escape by SARS-CoV-2; in particular, our studies point to the potential value of antibodycocktails in which twoantibodies …
KH Liang, PY Chiang, SH Ko, YC Chou, RM Lu… - Journal of Biomedical …, 2021 - Springer
… We next tested the therapeutic effects of the antibodycocktail administered after SARS-CoV-2 infection in the hamster model (Fig. 4). We treated hamsters with RBD-chAb-15 or -28 …
… strong neutralizing activity against SARS-CoV-2 and variants of concern … antibody features enable recognition of the SARS-CoV-2 spike RBD and demonstrate the utility of the cocktail …
J Hansen, A Baum, KE Pascal, V Russo, S Giordano… - Science, 2020 - science.org
… using both mice and humans to generate antibodies against the spike protein of severe acute respiratory syndrome coronavirus2 (SARS-CoV-2). The ability to derive antibodies using …
… a humanized anti-SARS-CoV-2antibodycocktail with therapeutic potential. … antibody cocktail. These structural information enhances our understanding of anti-SARS-CoV-2antibody-…
… two additional antibodies of this clonotype from our own panel of anti-SARS-CoV-2antibodies… As expected, given that these antibodies are members of a shared genetic clonotype, the …
N Wang, Y Sun, R Feng, Y Wang, Y Guo, L Zhang… - Cell research, 2021 - nature.com
… 10 against SARS-CoV-2 and SARS-CoV has a potential to constitute the fourth component for our cocktails (Fig. 1g), conferring synergy in protective efficacy against pan-SARS-CoVs …
DM Weinreich, S Sivapalasingam… - … England Journal of …, 2021 - Mass Medical Soc
… investigating REGN-COV2, an antibodycocktail containing twoSARS-CoV-2–neutralizing … with Ebola virus. Our analysis suggests that an antibodycocktail against SARS-CoV-2 can …
Y Sun, L Wang, R Feng, N Wang, Y Wang, D Zhu… - Cell research, 2021 - nature.com
… of the potential three- and four-antibodycocktails, we performed cryo-EM analysis of the SARS-CoV-2 S trimer in complex with two sets of multiple-antibodycocktails (FC05–H014–P17; …