Modeling the viral dynamics of SARS-CoV-2 infection

S Wang, Y Pan, Q Wang, H Miao, AN Brown… - Mathematical …, 2020 - Elsevier
… the pathogenic features of SARS-CoV-2 infection by examining the interaction between
the virus, cells and immune responses. Models are fit to the data of SARS-CoV-2 infection in …

Viral dynamics of SARS-CoV-2 across a spectrum of disease severity in COVID-19

G Lui, L Ling, CKC Lai, EYK Tso, KSC Fung… - Journal of …, 2020 - journalofinfection.com
… We observe two patterns of viral dynamics trajectory in the respiratory tract. In more severe
disease, viral load appeared to peak in the second week of illness in both upper and lower …

[HTML][HTML] SARS-CoV-2, SARS-CoV, and MERS-CoV viral load dynamics, duration of viral shedding, and infectiousness: a systematic review and meta-analysis

M Cevik, M Tate, O Lloyd, AE Maraolo, J Schafers… - The lancet …, 2021 - thelancet.com
… We retrieved all English-language research articles reporting viral dynamics or the duration
of shedding of SARS-CoV-2, SARS-CoV, or MERS-CoV in various specimens through …

[HTML][HTML] Viral dynamics of acute SARS-CoV-2 infection and applications to diagnostic and public health strategies

SM Kissler, JR Fauver, C Mack, SW Olesen, C Tai… - PLoS …, 2021 - journals.plos.org
… Similar phenomenological models have been used to study the viral dynamics of HIV [17].
More biologically explicit mechanistic models have been used to study SARS-CoV-2 [18,19], …

Viral dynamics of SARS-CoV-2 in saliva from infected patients

J Zhu, J Guo, Y Xu, X Chen - Journal of Infection, 2020 - journalofinfection.com
… demonstrated successful detection of SARS-CoV-2 RNA in … for the diagnosis and viral load
monitoring of SARS-CoV-2. … for the diagnosis and viral load monitoring of SARS-CoV-2 in a …

[HTML][HTML] Viral dynamics of SARS-CoV-2 variants in vaccinated and unvaccinated persons

SM Kissler, JR Fauver, C Mack, CG Tai… - … England Journal of …, 2021 - Mass Medical Soc
… Using a Bayesian hierarchical statistical model, 5 we compared SARS-CoV-2 viral
dynamics among 36 participants who were infected with the B.1.1.7 (alpha) variant, 36 …

Viral dynamics and duration of PCR positivity of the SARS-CoV-2 Omicron variant

JA Hay, SM Kissler, JR Fauver, C Mack, CG Tai… - MedRxiv, 2022 - medrxiv.org
… We extended a previously reported model for capturing SARS-CoV-2 viral kinetics to estimate
the viral proliferation time, viral clearance time, and peak viral load by variant and immune …

[HTML][HTML] SARS-CoV-2 viral dynamics in non-human primates

A Gonçalves, P Maisonnasse, F Donati… - PLoS computational …, 2021 - journals.plos.org
… with SARS-CoV-2 develop a mild infection resembling asymptomatic human infection. Here
we used viral dynamic modelling to characterize the nasopharyngeal and tracheal viral loads…

Viral dynamics of SARS-CoV-2 variants in vaccinated and unvaccinated individuals

SM Kissler, JR Fauver, C Mack, CG Tai, MI Breban… - MedRxiv, 2021 - medrxiv.org
… This study provides a detailed picture of acute SARS-CoV-2 viral dynamics for key variants
viral concentrations can play a valuable role in illuminating factors contributing to SARS-CoV-…

Modelling SARS-CoV-2 dynamics: implications for therapy

KS Kim, K Ejima, Y Ito, S Iwanami, H Ohashi, Y Koizumi… - MedRxiv, 2020 - medrxiv.org
… Furthermore, we used our viral dynamics model to predict the effectiveness of unlicensed
drugs that have different methods of action. The effectiveness was measured by AUC of …