Targeting Specific Checkpoints in the Management of SARS-CoV-2 Induced Cytokine Storm

A Rabiu Abubakar, R Ahmad, AB Rowaiye, S Rahman… - Life, 2022 - mdpi.com
… the complications of SARS-CoV-… cytokines known as cytokine storm syndrome. This article
reported the various checkpoints targeted to manage the SARS-CoV-2-induced cytokine storm

COVID‐19: Consider IL6 receptor antagonist for the therapy of cytokine storm syndrome in SARS‐CoV‐2 infected patients

C Chakraborty, AR Sharma… - Journal of medical …, 2020 - Wiley Online Library
patients, cytokine storm is involved and causes organ failure leading to death. The cytokine
storm, also called cytokine … several critical patients of COVID-19. It causes death of several …

SARS-CoV-2 infection and overactivation of Nlrp3 inflammasome as a trigger of cytokine storm” and risk factor for damage of hematopoietic stem cells

MZ Ratajczak, M Kucia - Leukemia, 2020 - nature.com
… the virus not only triggers cytokine storm but most likely also affects the stem cell compartment
in various organs and we may identify soon some remote consequences of SARS-CoV-2 …

The cytokine storm of COVID-19: a spotlight on prevention and protection

L Pearce, SM Davidson, DM Yellon - Expert Opinion on …, 2020 - Taylor & Francis
… associated with increased MAS and worsening cytokine storm [Citation8]. Moreover,
when type I IFNs have been introduced to SARS infected animals, lower levels of pro-inflammatory …

Targeting cytokine storm to manage patients with COVID-19: a mini-review

N Roshanravan, F Seif, A Ostadrahimi… - Archives of medical …, 2020 - Elsevier
… term “cytokine release syndrome” (CRS) or cytokine stormSARS-CoV-2 and its relationship
with the host cytokine storm. … hyper-inflammation in infected patients were mentioned. The …

Shelter from the cytokine storm: pitfalls and prospects in the development of SARS-CoV-2 vaccines for an elderly population

A Ciabattini, P Garagnani, F Santoro… - Seminars in …, 2020 - Springer
… and worsen the prognosis of SARS-CoV-2 infection. … cytokines, termed the “cytokine storm
syndrome.” This is a condition reported in severe COVID-19 cases during which the patient’s …

Cytokine storm and COVID-19: a chronicle of pro-inflammatory cytokines

A Fara, Z Mitrev, RA Rosalia, BM Assas - Open biology, 2020 - royalsocietypublishing.org
… As observed in SARS-Cov-1 and MERS, IL-6 is generated early in the infection as a result …
Notably, evidence for IL-6 production enhancement in SARS-Cov-1 pathogenesis [60] builds …

Anti-SARS-CoV-2 and anti-cytokine storm neutralizing antibody therapies against COVID-19: Update, challenges, and perspectives

CM Batista, L Foti - International Immunopharmacology, 2021 - Elsevier
cytokine storm has been observed in patients with severe disease characterized by a
proinflammatory cytokine … Thus, some treatment strategies focus on anti-cytokine storm nAbs. This …

Storm at the time of corona: a glimpse at the current understanding and therapeutic opportunities of the SARS-CoV-2 cytokine storm

M Torabi-Rahvar, N Rezaei - Current Pharmaceutical Design, 2021 - ingentaconnect.com
… that was observed in SARS and MERS, suggesting that the “cytokine storm” may also have a
… Accordingly, the following sections discuss the mechanisms of the cytokine storm in COVID-…

Cytokine drizzle—the rationale for abandoning “cytokine storm

AE Stolarski, J Kim, Q Zhang, DG Remick - Shock, 2021 - journals.lww.com
… by SARS CoV-2. The threshold of blood cytokines necessary to qualify as a “cytokine storm
… We propose eliminating the term “cytokine storm” as there is no clear threshold of cytokine