Repurposing of drugs targeting the cytokine storm induced by SARS‐CoV‐2

WH Ng, PCH Tang, S Mahalingam… - British Journal of …, 2023 - Wiley Online Library
… Anti-cytokine … for SARS-CoV-2-induced ARDS, in which the cytokine storm plays an
immunopathological role. This minireview includes anti-cytokine drugs tested in COVID-19 patients, …

[HTML][HTML] Intricate relationship between SARS-CoV-2–induced shedding and cytokine storm generation: A signaling inflammatory pathway augmenting COVID-19

MB Moftah, A Eswayah - Health Sciences Review, 2022 - Elsevier
… (SARS-CoV-2), through its ability to induce cytokine release … potentiate the cytokine storm
during an episode of SARS-CoV-… -2) as the main target for SARS-CoV-2 is highlighted in detail …

Can molecular mimicry explain the cytokine storm of SARS‐CoV‐2?: An in silico approach

G Obando‐Pereda - Journal of medical virology, 2021 - Wiley Online Library
… the SARS-CoV-2 related cytokine storm by a hyper-inflammatory state as well as by the
MAS. In this manner, this study demonstrated that PARP9 could be depressed by the same …

Immune response to SARS‐CoV‐2 and mechanisms of immunopathological changes in COVID‐19

AK Azkur, M Akdis, D Azkur, M Sokolowska… - Allergy, 2020 - Wiley Online Library
… changes in patients linked to deteriorating clinical conditions such as cytokine storm, acute
SARS patients were found to have higher plasma Fas-ligand levels, associated with higher …

Prevention of the cytokine storm in COVID-19

DJM Wright - The Lancet Infectious Diseases, 2021 - thelancet.com
… transient manifestation of a cytokine storm, induced by treatment … -19 in patients presenting
with a cytokine storm and in those … had tested positive for SARS-CoV-2, the patient underwent …

T cell immunobiology and cytokine storm of COVID‐19

XH Luo, Y Zhu, J Mao, RC Du - Scandinavian journal of …, 2021 - Wiley Online Library
SARS is an instance of cytokine storms that give rise to a … Similarly, cytokine storm is a
critical profile of patients with … expression of IL-6. Higher plasma concentrations of IL-2, IL2R, …

[HTML][HTML] The potential for Lactoferrin to reduce SARS-CoV-2 induced cytokine storm

M Zimecki, JK Actor, ML Kruzel - International Immunopharmacology, 2021 - Elsevier
… by severe acute respiratory syndrome of coronavirus 2 (SARS-CoV-2). Symptoms of
COVID-… as a “cytokine storm”. In fact, this massive release of inflammatory cytokines into in the …

Cytokine storm and use of anakinra in a patient with COVID-19

P Nemchand, H Tahir, R Mediwake… - BMJ Case Reports …, 2020 - casereports.bmj.com
… Our case suggests that the administration of anakinra in SARS-CoV-2-induced cytokine storm
… We suggest that earlier identification of patients developing cytokine storm and COVID-19 …

Silibinin and SARS-CoV-2: dual targeting of host cytokine storm and virus replication machinery for clinical management of COVID-19 patients

J Bosch-Barrera, B Martin-Castillo, M Buxó… - Journal of clinical …, 2020 - mdpi.com
Patients with severe disease had also elevated … in patients [4]. These initial findings were
consistent with a clinical scenario in which the presence of hypercytokinemia (cytokine storm

[HTML][HTML] Aveolar macrophage activation and cytokine storm in the pathogenesis of severe COVID-19

C Wang, J Xie, L Zhao, X Fei, H Zhang, Y Tan, L Zhou… - 2020 - europepmc.org
… compared to that found in SARS patients. The hyaline membranes … SARS-CoV–2 and
potential drivers of “cytokine storm syndrome” in COVID–19. Additionally, an elevated serum IL6