11 天前 - … relevant model of human striatal development in a dish. … These DEGs included
several genome-wide association … likewise revealed upregulation of synaptic genes. Overall, …

56 天前 - … Genes encoding machinery for synaptic development and plasticity … genome-wide
association studies for schizophrenia and autism. They found that locally translated synaptic …

69 天前 - … have mainly focused on the protein-coding part of the genome; in this context, the
roles … schizophrenia-like phenotypes and inflammatory processes that are linked to synaptic …

74 天前 - … precipitate functional disruptions in synaptic transmission and neurodegeneration.
… in the prevention of psychosis during adulthood, as this is more likely to develop with age, …

115 天前 - … Based on genomic analyses, we discuss how disease-related mutations in Ras
and … Proper synaptic development and plasticity also require GEFs and GAPs that modulate …

121 天前 - … associated with schizophrenia based on 22 findings from large-scale genomic
studies. … of ZNF804A mutation on developing glutamatergic 404 synapses, we examined the …

140 天前 - … While genome-wide association studies have identified 120 gene loci associated
with … suggest that schizophrenia risk may be mediated by abnormal synaptic development and …

178 天前 - … sites across the whole genome which can actively jump … and phosphatase regulation
plus synaptic functioning was … novel biomarkers and to develop new therapy strategies, …

216 天前 - … development, and synaptic plasticity. Alterations in endogenous BDNF levels have
been associated with neurological disorders, such as schizophrenia … known about genome-…

227 天前 - … Genomics Consortium (PGC), in which 108 distinct loci across the genome were
associated with schizophrenia … that schizophrenia results from disrupted synaptic signaling and …