The genesis of schizophrenia: an origin story

R Birnbaum, DR Weinberger - American Journal of Psychiatry, 2024 - Am Psychiatric Assoc
… analyses found that genes within reported schizophrenia genome-wide association study
(… , including synaptic functions implicated in brain development. Rare variant discovery in …

[PDF][PDF] The synaptic hypothesis of schizophrenia

WG Frankle, J Lerma, M Laruelle - Neuron, 2003 - cell.com
schizophrenia. If the vulnerability to the illness is mediated by a lower synaptic synaptic
organization, both in development … to dysfunction of synapgenomic variabilities associated with …

[HTML][HTML] Synaptic and gene regulatory mechanisms in schizophrenia, autism, and 22q11. 2 copy number variant–mediated risk for neuropsychiatric disorders

JK Forsyth, D Nachun, MJ Gandal, DH Geschwind… - Biological …, 2020 - Elsevier
… Using a functional genomics approach, we integrated transcriptomic data from the developing
human brain, genome-wide association findings for SCZ and ASD, protein interaction data…

Strong synaptic transmission impact by copy number variations in schizophrenia

JT Glessner, MP Reilly, CE Kim… - Proceedings of the …, 2010 - National Acad Sciences
schizophrenia, we performed a whole-genome CNV analysis on a cohort of 977 schizophrenia
… genes that are essential for brain development and function and of potential relevance to …

MIR137 schizophrenia-associated locus controls synaptic function by regulating synaptogenesis, synapse maturation and synaptic transmission

E He, MAG Lozano, S Stringer… - Human molecular …, 2018 - academic.oup.com
development, LTP and synaptic functions, possibly by a rather selective effect on the
expression a few synaptic … the Psychiatric Genomics Consortium (PGC) schizophrenia genome-…

Synaptic dysfunction in schizophrenia

DM Yin, YJ Chen, A Sathyamurthy, WC Xiong… - … : Dynamics, Development …, 2012 - Springer
… the relationship between synaptic transmission and schizophrenia. We will … synapses in
schizophrenia and discuss the roles of susceptibility genes in neural development and synaptic

Mapping the consequences of impaired synaptic plasticity in schizophrenia through development: an integrative model for diverse clinical features

JK Forsyth, DA Lewis - Trends in cognitive sciences, 2017 - cell.com
… determined impairments in synaptic plasticity interact with … development. Finally, we suggest
possible mechanisms through which impaired synaptic plasticity might lead to psychosis. …

[HTML][HTML] Fifty years of research on schizophrenia: the ascendance of the glutamatergic synapse

JT Coyle, WB Ruzicka, DT Balu - American Journal of …, 2020 - Am Psychiatric Assoc
… of schizophrenia (1) was proposed, the first report of synaptic … the probability of developing
schizophrenia and interact with … on schizophrenia, published in 2014 and involving genomes

Genetics implicate common mechanisms in autism and schizophrenia: synaptic activity and immunity

X Liu, Z Li, C Fan, D Zhang, J Chen - Journal of medical genetics, 2017 - jmg.bmj.com
… more recent genome-wide association studies (GWAS), which enables scanning entire genomes
for … these different pathways in brain development and synaptic function can explain the …

Protein interaction networks link schizophrenia risk loci to synaptic function

E Schwarz, R Izmailov, P Liò… - Schizophrenia …, 2016 - academic.oup.com
… Here, we develop a novel strategy based on network … show that the schizophrenia loci are
strongly linked to synaptic … previously linked to schizophrenia by genome-wide enrichment …