[PDF][PDF] Schizophrenia genetics: new insights from new approaches.

HJ Williams, MJ Owen, MC O'Donovan - British medical bulletin, 2009 - Citeseer
… that schizophrenia is neurodevelopmental and that synaptic … study designs based upon
genome-wide association studies (… role in the development of normal synaptic function.Based …

Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia

LM Camargo, V Collura, JC Rain, K Mizuguchi… - Molecular …, 2007 - nature.com
… critical for the formation of synapses namely synaptic activity mediated by the … development,
maturation and plasticity of synapses, and which may also be linked to schizophrenia

Dynamic expression of genes associated with schizophrenia and bipolar disorder across development

NE Clifton, E Hannon, JC Harwood, A Di Florio… - Translational …, 2019 - nature.com
synaptic pruning and elimination of excitatory synapses … for schizophrenia and bipolar
disorder as identified in genome-… However, rarer but more penetrant genomic risk variants, …

Schizophrenia genes, gene expression, and neuropathology: on the matter of their convergence

PJ Harrison, DR Weinberger - Molecular psychiatry, 2005 - nature.com
… the mechanism by which it predisposes to schizophrenia been identified. Nevertheless, we
… upon schizophrenia risk via an influence upon synaptic plasticity and the development and …

The integrated landscape of causal genes and pathways in schizophrenia

C Ma, C Gu, Y Huo, X Li, XJ Luo - Translational psychiatry, 2018 - nature.com
… We found that synaptic transmission-related genes were … genes for schizophrenia, we
systematically integrated genome-… a role in schizophrenia by affecting brain development. MMP16 …

Epigenetic mechanisms in schizophrenia

S Akbarian - Dialogues in clinical neuroscience, 2014 - Taylor & Francis
… epigenetic determinants of genome organization and function … expression of synaptic and
metabolic genes in schizophrenia brain, … to promote rational drug development in SCZ, mainly …

Schizophrenia risk from complex variation of complement component 4

…, Schizophrenia Working Group of the Psychiatric … - Nature, 2016 - nature.com
… elimination during postnatal development. These … development of schizophrenia and may
help explain the reduced numbers of synapses in the brains of individuals with schizophrenia. …

Genome-wide expression analysis reveals dysregulation of myelination-related genes in chronic schizophrenia

Y Hakak, JR Walker, C Li, WH Wong… - Proceedings of the …, 2001 - National Acad Sciences
schizophrenia and control samples. We report that the expression levels of genes involved in
neuronal myelination, development, synaptic … prefrontal cortex of schizophrenia brain tissue…

Schizophrenia: a tale of two critical periods for prefrontal cortical development

LD Selemon, N Zecevic - Translational psychiatry, 2015 - nature.com
Development of the prefrontal cortex in its earliest stage in … for schizophrenia in which
cell proliferation and synaptic … In this regard, recent genome-wide association studies have …

Brain-derived neurotrophic factor and schizophrenia

P Di Carlo, G Punzi, G Ursini - Psychiatric genetics, 2019 - journals.lww.com
… altered synaptic plasticity and neurodevelopment. However, … gene in schizophrenia, thus
informing development of brain-… liability of schizophrenia ( Psychiatric Genomics Consortium, …