… trios, and copy number variants from 6,882 cases and 11,255 controls, we show that individuals
with schizophrenia carry a significant burden of rare, damaging variants in 3,488 genes …

… , we found that selecting individuals with extremely severe forms of schizophrenia led to a
… -associated rare variants. The high prevalence of rare variant risk factors in individuals with …

… Studies involving parents and offspring suggest that a high proportion of CNVs at identified
schizophrenia loci are de novo in the individuals in which they occur (for example, >80% of …

… individuals in the general population in terms of structural variation. The frequency of these
variants is relatively lower than the single nucleotide variants, … studied in individuals affected …

… To assess these variables with respect to clinically relevant rare variant burden, we used a
… There was no overlap of individuals in the training dataset with our schizophrenia cohort (…

… famSKAT is a statistical strategy that uses sequence kernel association to evaluate rare
variants in samples that contain related individuals [56] . FamBT is a burden analysis that can be …

… in this study and the fact that we are looking at rare variants. … the individuals carrying variants
in SBNO1 and found that the signal was driven by variants shared by a subset of individuals…

… of schizophrenia. We observe an overlap of rare variant risk among schizophrenia, autism
… sufficient power to evaluate the individual schizophrenia risk genes associated in our study …

… rare variants in schizophrenia, and some (but not a substantial part) of the polygenic contribution
that was observed in the International Schizophrenia … schizophrenia in those individuals …

… gene is likely to have rare variants that explain even 1% of schizophrenia cases. … rare
variants and schizophrenia, we identified in schizophrenia cases an ultra-rare splice donor variant …