… array of age-related pathologies. Recent biomedical advances in specifically targeting
senescent cells to improve healthy aging, or alternatively, postpone natural aging and age-related …

… our knowledge of whether senescent cells contribute to organismal aging and age-related …
senescent cells, representing a major advance in aging biology and geriatric medicine. …

… senescent cells in vivo predicts “molecular,” as opposed to chronologic, age and that senescent
cell clearance may mitigate aging-… In young healthy organisms, therefore, expression of …

… significantly increased incidence of the most common age-related diseases (ARDs). Senescent
cells (SCs) have been identified as culprits of organismal aging. Their number rises with …

… between cellular senescence and age-associated complications and highlight novel therapeutic
avenues that may be exploited to target senescent cells … Stem cells and healthy aging. …

… that senescent cells play a causative role in ageing and age-related disease. Therefore,
the development of drugs that specifically kill senescent cells … phenotypes, treating age-related …

… relate to the role of senescent cells in ageing and age-related … senescent cell populations
selectively to improve healthy … age-related increases in senescent cells, or that chronically …

… indicate that selective elimination of senescent cells can delay age-related deterioration. …
by senescent cells might be a main driver of these pathologies. Importantly, senescent cells …

… Cellular senescence is followed by senescent cell clearance … of senescent cells does not
occur, senescent cells … standard“) of cellular aging process or the healthy aging of the organism. …

… Transplanting senescent cells into middle-aged mice so that only 1 in 10 000 … Senescent
cell burden is usually low in healthy people through middle age but increases across several …