… senescence in human non-senescent cells and amplifies the SASP in human senescent cells
via … is up-regulated in human senescent compared to non-senescent cells [54]. Importantly, …

… proliferation, but it decreases the health of the old by littering tissues with dysfunctional
senescent cells (SNCs). In mice, the selective elimination of SNCs (senolysis) extends median …

… cell cycle arrest after experiencing inherent or environmental stresses. Although cellular
senescence is … advances in specifically targeting senescent cells to improve healthy aging, or …

… Senescent cells are characterized by several features including … senescent cells undergoing
either replicative senescence or … , seem to be a promising strategy for prolonging healthy …

… with premature aging phenotypes, including cellular senescence, inflammation, cardiac …
essential for protecting against senescence, diseases, and for promoting healthy longevity. …

… It is not known whether in longliving people there is an accumulation of senescent cells,
as … cells from healthy elderly and centenarians. Mech Ageing Dev 2000; 121: 239-50. …

… The rat closely recapitulates human physiology and pathophysiology and can be used to
study aspects of aging, including longevity, senescence-related pathology, and pharmacologic …

… We describe mechanisms by which senescent cells drive aging and diseases, and we discuss
… Consistently, in a young healthy individual senescent cells can be induced successfully …

… These immune signatures of supercentenarians well explain that the increased healthy
longevity is due to immunosurveillance of some conditions such as infections [128] and tumor …

… senescent cells from the body. Selectively targeting p16 Ink4a -positive senescent cells for
… related accumulation of senescent cells, suggesting that senescent immune cells could be a …