Anakinra combined with methylprednisolone in patients with severe COVID-19 pneumonia and hyperinflammation: An observational cohort study

G Bozzi, D Mangioni, F Minoia, S Aliberti… - Journal of Allergy and …, 2021 - Elsevier
… We sought to determine efficacy and safety of the association of IL-1 receptor antagonist
anakinra plus methylprednisolone in severe COVID-19 pneumonia with hyperinflammation. …

Interleukin-6 blockade with sarilumab in severe COVID-19 pneumonia with systemic hyperinflammation: an open-label cohort study

E Della-Torre, C Campochiaro, G Cavalli… - Annals of the …, 2020 - ard.bmj.com
… and systemic hyperinflammation. Methods We conducted an open-label study of sarilumab
in severe COVID-19 pneumonia (PaO 2 /FiO 2 <300 mm Hg) with hyperinflammation (…

Tocilizumab for the treatment of severe COVID-19 pneumonia with hyperinflammatory syndrome and acute respiratory failure: a single center study of 100 patients in …

P Toniati, S Piva, M Cattalini, E Garrafa, F Regola… - Autoimmunity …, 2020 - Elsevier
… During the 10-day follow-up, three cases of severe adverse events were recorded: two …
In conclusion, our series showed that COVID-19 pneumonia with ARDS was characterized …

[HTML][HTML] Lymphopenic community acquired pneumonia as signature of severe COVID-19 infection

JF Bermejo-Martin, R Almansa, R Menendez… - The Journal of …, 2020 - ncbi.nlm.nih.gov
… Endothelial dysfunction induces also increased oxidative stress and systemic inflammation,
glycocalyx degradation and shedding along with a pro-coagulant and anti-fibrinolytic state [9]…

[HTML][HTML] Immunopathology of Hyperinflammation in COVID-19

JN Gustine, D Jones - The American journal of pathology, 2021 - Elsevier
hyperinflammatory syndrome in severe COVID-19 is provided. The current evidence suggests
that the hyperinflammatory … to the hospital with COVID-19–related pneumonia in Wuhan, …

Severe COVID-19: immunosuppression or hyperinflammation?

Y Liu, Y Li, D Xu, J Zhang, Z Peng - Shock, 2021 - journals.lww.com
… unknown pneumonia named subsequently as coronavirus … of coexistence of hyperinflammation
and immunosuppression … about immune states of COVID-19 in severe patients and the …

GM-CSF blockade with mavrilimumab in severe COVID-19 pneumonia and systemic hyperinflammation: a single-centre, prospective cohort study

G De Luca, G Cavalli, C Campochiaro… - The Lancet …, 2020 - thelancet.com
… data see the Coronavirus Resource … COVID-19 pandemic. Accumulating evidence suggests
that a subgroup of patients with severe COVID-19 pneumonia develop a hyperinflammatory

Mavrilimumab in patients with severe COVID-19 pneumonia and systemic hyperinflammation (MASH-COVID): an investigator initiated, multicentre, double-blind …

PC Cremer, A Abbate, K Hudock… - The Lancet …, 2021 - thelancet.com
… of patients with COVID-19 pneumonia and hyperinflammation treated with mavrilimumab, …
in patients with COVID-19 pneumonia, hypoxaemia, and hyperinflammation. The primary …

Interleukin-6 receptor blockade with subcutaneous tocilizumab in severe COVID-19 pneumonia and hyperinflammation: a case–control study

N Potere, M Di Nisio, D Cibelli, R Scurti… - Annals of the …, 2021 - ard.bmj.com
COVID-19 pneumonia (involving ≥20% of lung parenchyma on chest CT), hyperinflammation
(CRP … We reviewed all patients hospitalised for COVID-19 pneumonia when TCZ was not …

… after treatment with corticosteroids alone or with tocilizumab in patients with severe COVID-19 pneumonia and moderate hyperinflammation. A retrospective cohort …

IF Aomar-Millán, J Salvatierra, Ú Torres-Parejo… - Internal and emergency …, 2021 - Springer
… In conclusion, the use of anakinra in patients with moderate hyperinflammation associated
with severe COVID-19 pneumonia after previous failure of corticosteroids alone or with …