Intravenous high-dose vitamin C for the treatment of severe COVID-19: study protocol for a multicentre randomised controlled trial

F Liu, Y Zhu, J Zhang, Y Li, Z Peng - BMJ open, 2020 - bmjopen.bmj.com
… This is one of the first clinical trials applying HIVC to treat COVID-19, and it will provide …
by COVID-19, help improve pulmonary function and reduce the risk of ARDS of COVID-19. …

Evaluation of the efficacy and safety of intravenous remdesivir in adult patients with severe COVID-19: study protocol for a phase 3 randomized, double-blind, placebo …

Y Wang, F Zhou, D Zhang, J Zhao, R Du, Y Hu… - Trials, 2020 - Springer
… It is also inhibitory against the COVID-19 virus in vitro. The aim of this study is to assess
the efficacy and safety of remdesivir in adult patients with severe COVID-19. …

Severe covid-19 pneumonia: pathogenesis and clinical management

AH Attaway, RG Scheraga, A Bhimraj, M Biehl… - bmj, 2021 - bmj.com
… ) has posed immense challenges for the research and medical communities. This review …
In formulating this review, we considered guidelines that provide recommendations on the …

… in patients with severe COVID-19 registered in the International Severe Acute Respiratory and Emerging Infection Consortium WHO clinical characterisation protocol …

LF Reyes, S Murthy, E Garcia-Gallo, M Irvine… - … open research, 2022 - Eur Respiratory Soc
severe COVID-19 patients can safely be cared for outside of an ICU [12]. Here, we describe
a global population of patients with severe COVID-19, … patients with severe COVID-19 inside …

Efficacy of dexamethasone treatment for patients with the acute respiratory distress syndrome caused by COVID-19: study protocol for a randomized controlled …

J Villar, JM Añón, C Ferrando, G Aguilar, T Muñoz… - Trials, 2020 - Springer
… of this study based on the positive results of a recent clinical trial, … Our goal in this study is to
examine the effects of … moderate-to-severe ARDS due to confirmed COVID-19 who still meet …

Invasive pulmonary aspergillosis in critically ill patients with severe COVID-19 pneumonia: Results from the prospective AspCOVID-19 study

T Lahmer, S Kriescher, A Herner, K Rothe, CD Spinner… - PloS one, 2021 - journals.plos.org
… screened 32 critically ill patients with severe COVID-19 pneumonia for a time period of
28 days using a standardized study protocol for oberservation of developement of COVID-…

Evaluation of the efficacy and safety of icatibant and C1 esterase/kallikrein inhibitor in severe COVID-19: study protocol for a three-armed randomized controlled trial

E Mansour, FF Bueno, JC de Lima-Júnior, A Palma… - Trials, 2021 - Springer
… In animal models, the inactivation of ACE2 leads to severe acute pneumonitis in response to
… We believe that inhibition of bradykinin in severe COVID-19 patients could reduce the lung …

Severe covid-19

DA Berlin, RM Gulick, FJ Martinez - New England Journal of …, 2020 - Mass Medical Soc
Guidelines The recommendations in this article are largely concordant with the guidelines
for severe Covid-19 … pneumonia: a randomized clinical trial. JAMA Intern Med 2020 October …

… of Acute Respiratory Distress Syndrome by Stromal Cell Administration in COVID-19 (REALIST-COVID-19): A structured summary of a study protocol for a randomised …

E Gorman, M Shankar-Hari, P Hopkins, WS Tunnicliffe… - Trials, 2020 - Springer
… Submissions were made to the Research Ethics Committee (REC) and MHRA to amend
the protocol to a COVID-19 specific patient population and the protocol amendment was …

… and efficacy assessment of allogeneic human dental pulp stem cells to treat patients with severe COVID-19: structured summary of a study protocol for a randomized …

Q Ye, H Wang, X Xia, C Zhou, Z Liu, Z Xia, Z Zhang… - Trials, 2020 - Springer
… human dental pulp stem cells (DPSCs) in treating severe pneumonia caused by COVID-19. …
, parallel group, clinical trial. Participants: Twenty serious COVID-19 cases will be enrolled in …