[HTML][HTML] The signal pathways and treatment of cytokine storm in COVID-19

L Yang, X Xie, Z Tu, J Fu, D Xu, Y Zhou - Signal transduction and …, 2021 - nature.com
… of the different cytokines involved. We also discuss the induction, function, … signaling, and
existing and potential interventions for targeting these cytokines or related signal pathways. We …

[HTML][HTML] The 'cytokine storm': molecular mechanisms and therapeutic prospects

R Karki, TD Kanneganti - Trends in immunology, 2021 - cell.com
Cytokine storm syndrome (CSS) has … these cytokine-mediated inflammatory PCD pathways
as ‘PANoptosis’, a PCD activated by pathogens, such as influenza A virus (IAV), by cytokines, …

The cytokine storm and COVID‐19

B Hu, S Huang, L Yin - Journal of medical virology, 2021 - Wiley Online Library
… immune responses of pathogenic Th1 cells and intermediate CD14 + CD16 + monocytes
are mediated by membrane-bound immune receptors and downstream signaling pathways. …

Role of toll‐like receptors in modulation of cytokine storm signaling in SARS‐CoV‐2‐induced COVID‐19

M Manik, RK Singh - Journal of medical virology, 2022 - Wiley Online Library
… The binding of TLRs occurs with the virus and may lead to the activation of NF-κB and
MAPK signaling pathways to facilitate viral clearance and produce antiviral responses. To …

Cytokine storm induced by SARS-CoV-2

P Song, W Li, J Xie, Y Hou, C You - Clinica chimica acta, 2020 - Elsevier
cytokine storm is induced by the virus will be introduced in detail, including the ways in which
cytokines … NF-κB transcriptional signaling pathway and the binding site of the nuclear factor …

The advent of the cytokine storm

IA Clark - Immunology and cell biology, 2007 - search.proquest.com
… The role of excessive release of such cytokines in pancreatitis, … The first use of cytokine
storm to describe the mechanism of … Although cytokine storm can be a useful lay term, we must …

The cytokine storm of COVID-19: a spotlight on prevention and protection

L Pearce, SM Davidson, DM Yellon - Expert Opinion on …, 2020 - Taylor & Francis
… The IL-6 ‘classical’ pathway involves the IL-6 receptor (IL-6 R) which binds directly to gp130.
The ‘trans’ signaling pathway uses soluble sIL-6 receptors to aid gp130 binding and signal

The triumvirate of NF-κB, inflammation and cytokine storm in COVID-19

A Attiq, LJ Yao, S Afzal, MA Khan - International immunopharmacology, 2021 - Elsevier
… The final activation sequence involves the NF-κB cross-talk with numerous cytokine and
TLR-mediated cell signalling pathways that depend upon the binding of TNFα and IL-1 to TLR4. …

Into the eye of the cytokine storm

JR Tisoncik, MJ Korth, CP Simmons… - Microbiology and …, 2012 - Am Soc Microbiol
… a cytokine storm and the biological consequences of cytokine overproduction. We will also
look at the cytokine storm … The redundancy of the cytokine and chemokine signaling pathways

Tocilizumab: a therapeutic option for the treatment of cytokine storm syndrome in COVID-19

A Saha, AR Sharma, M Bhattacharya, G Sharma… - Archives of medical …, 2020 - Elsevier
… and there are two types of signaling pathways (classical and trans signaling pathway) have
… the classical pathway, IL-6 bind to its receptor ie mIL-6R (membrane bound receptor for IL-6) …