Targeting the “cytokine storm” for therapeutic benefit

RV D'Elia, K Harrison, PC Oyston… - Clinical and Vaccine …, 2013 - Am Soc Microbiol
… In addition, the development of broad-spectrum chemokine inhibitors (BSCIs) that can affect
multiple chemokine signaling pathways simultaneously while leaving other cytokine signals

Toll-like receptors in sepsis-associated cytokine storm and their endogenous negative regulators as future immunomodulatory targets

V Kumar - International immunopharmacology, 2020 - Elsevier
storm and discusses various host-derived endogenous negative regulators of TLR signaling
pathways. … for developing novel therapeutic drugs for cytokine storm-associated diseases, …

[HTML][HTML] How COVID-19 induces cytokine storm with high mortality

S Hojyo, M Uchida, K Tanaka, R Hasebe… - Inflammation and …, 2020 - Springer
… transducer and activator of transcription 3 (STAT3) and NF-κB signaling in non-… IL-6-STAT3
signaling is a promising therapeutic target for the cytokine storm in COVID-19, because IL-6

Cytokine storm and COVID-19: a chronicle of pro-inflammatory cytokines

A Fara, Z Mitrev, RA Rosalia, BM Assas - Open biology, 2020 - royalsocietypublishing.org
cytokine levels while discussing cytokine sources and biological functions. Finally, we discuss
in brief potential therapies attempting to modulate the cytokine storm. … signalling pathways

[HTML][HTML] Interplay between interleukin-6 signaling and the vascular endothelium in cytokine storms

S Kang, T Kishimoto - Experimental & molecular medicine, 2021 - nature.com
… Here, we highlight the distinct contributions of IL-6 signaling to the pathogenesis of several
cytokines, and signaling pathways is critically involved in the pathogenesis of cytokine storms

The roles of critical pro‐inflammatory cytokines in the drive of cytokine storm during SARS‐CoV‐2 infection

MS Qudus, M Tian, S Sirajuddin, S Liu… - Journal of Medical …, 2023 - Wiley Online Library
cytokine or inhibitor of some inflammatory signal pathways. … of cytokine and chemokine
secretions resulting from host immunological responses to SARS-CoV-2 infection, cytokine storm (…

The cytokine storm in COVID-19: An overview of the involvement of the chemokine/chemokine-receptor system

F Coperchini, L Chiovato, L Croce, F Magri… - Cytokine & growth factor …, 2020 - Elsevier
… Moreover, an up-regulation of several genes involved in apoptosis and P53 signaling
pathways in PBMC was observed, leading to the hypothesis that this process could be the …

Calming the cytokine storm of COVID-19 through inhibition of JAK2/STAT3 signaling

BK Gajjela, MM Zhou - Drug discovery today, 2022 - Elsevier
… virus-caused massive tissue damage that is associated with uncontrolled cytokine release,
known as a cytokine storm, through JAK/STAT signaling pathways. Here, we review the FDA-…

Role of the innate cytokine storm induced by the influenza A virus

Y Gu, ACY Hsu, Z Pang, H Pan, X Zuo, G Wang… - Viral …, 2019 - liebertpub.com
… on cytokine storms and their signaling pathwaysstorms, and this can lead to multiple organ
dysfunctions (12). In this review, we focus on cytokine storms and their signaling pathways

[PDF][PDF] Cytokine storm

M Gaestel, AR Nebreda, MB Yaffe - 2021 - dspace.mit.edu
… disorders, we mentioned MAPK only briefly, but we did include it as one of the four signaling
pathways. We agree with the comment by Supady et al. that cytokine storm after cardiac …