… of the different cytokines involved. We also discuss the induction, function, … signaling, and
existing and potential interventions for targeting these cytokines or related signal pathways. We …

… signaling pathways will be activated [84]. The corresponding adaptor molecules such as
IL-1 receptor-associated kinase 1 (RAK-1) and tumor necrosis factor receptor-associated factor …

… ; together, these pathways provide a framework for molecularly defining the CS. We refer
to the crosstalk between these cytokine-mediated inflammatory PCD pathways as ‘PANoptosis’, …

… immune responses of pathogenic Th1 cells and intermediate CD14 + CD16 + monocytes
are mediated by membrane-bound immune receptors and downstream signaling pathways. …

… (10) use the transcriptome dataset approach to discover that SARS-CoV-2 can activate
apoptosis and P53 signaling pathway (one of the pathways responsible for the survival of the cell…

… The final activation sequence involves the NF-κB cross-talk with numerous cytokine and
TLR-mediated cell signalling pathways that depend upon the binding of TNFα and IL-1 to TLR4. …

… and there are two types of signaling pathways (classical and trans signaling pathway) have
… the classical pathway, IL-6 bind to its receptor ie mIL-6R (membrane bound receptor for IL-6) …

… IL-6 or Janus kinase (JAK) pathway … treatments for the cytokine storm in severe COVID-19.
Last, we propose the potential of therapeutic plasma exchange (TPE) to treat cytokine storm in …

… Finally, they might block the production of pro-inflammatory cytokines including IL-6, thereby
blocking the pathway that subsequently leads to ARDS. Whatever the mechanisms are, …

… -I signaling pathways, or those who had autoantibodies that recognized type I interferons.
The route of administration of interferon-based therapies may also play a factor. Since the …