… :4 and 8:4, the Myddosome. Formation of the Myddosome is likely to be a key event for TLR4
signaling … oligomeric signaling platform analogous to the death-inducing signaling complex …

… platform that employs IL-1R-associated kinase (IRAK) proteins as main players for transducing
signals. … This review will discuss how IRAK proteins regulate myddosome signaling: from …

… signaling platform comprising myeloid differentiation primary response 88 (MyD88) and
members of the interleukin-1 receptor–associated kinase (IRAK… downstream signaling pathways. …

… of IRAK dependency in human and mouse TLR signaling, in addition to identifying a clear
difference in pathway architecture between species, also validated our screening platform for …

… The MyDDosome provides the necessary activation platform for IRAKs: Only once in the
MyDDosome can IRAK4 dimerize and trans-autophosphorylate, resulting in its activation (23–26…

… and IRAK4 form an oligomeric complex, termed the Myddosome, which acts as a platform for
the recruitment of the other members of the IRAK … IRAK1 and IRAK4 are catalytically active …

… the role of IRAK4 in immune signaling and offered the … The pathway by which IRAK4 signals
immune response has … upstream drivers of the signaling cascade (IRAK4 is downstream of …

… mechanism of dysfunction of two IRAK4 PID variants, G298D … of IRAK4's scaffolding and
kinase activities to IL1R signaling, we … signaling and cytokine production. Quantitation of IL-1 …

… We assayed the dynamics of MyD88 and IRAK4 co assembly in live cells in the presence
of a IRAK4 kinase inhibitor24, that blocks downstream signaling and inhibited IRAK4 …

… initiates the intracellular signaling cascade by providing a docking platform for the adaptor
… Similarly, we cannot exclude that a so far unknown signaling pathway downstream of IRAK4 …