In silico analysis of SARS-CoV-2 proteins as targets for clinically available drugs

WKB Chan, KM Olson, JW Wotring, JZ Sexton… - Scientific Reports, 2022 - nature.com
… acute respiratory syndrome coronavirus 2 (SARS-CoV-2) … drugs with potential activity against
SARS-CoV-2 at traditional and … putative binding sites across 23 SARS-CoV-2 proteins. We …

[HTML][HTML] Role of changes in SARS-CoV-2 spike protein in the interaction with the human ACE2 receptor: An in silico analysis

JT Ortega, ML Serrano, FH Pujol, HR Rangel - EXCLI journal, 2020 - ncbi.nlm.nih.gov
… magnitude is the Covid-19 epidemics caused by SARS-CoV-2. The aim of this study was to
… the SARS-CoV-2 that might be favoring human to human transmission. An in silico approach …

In silico analyses on the comparative sensing of SARSCoV‐2 mRNA by the intracellular TLRs of humans

A Choudhury, NC Das, R Patra… - Journal of Medical …, 2021 - Wiley Online Library
… binding of the major SARS-CoV-2 mRNAs to the … in silico study on the binding of all mRNAs
with the intracellular TLRs depicts that the mRNA of NSP10, S2, and E proteins of SARS-CoV

[HTML][HTML] In-silico analysis of the inhibition of the SARS-CoV-2 main protease by some active compounds from selected African plants

HI Umar, SS Josiah, TP Saliu, TO Jimoh, A Ajayi… - Journal of Taibah …, 2021 - Elsevier
Objectives Over the years, Azadirachta indica, Mangifera indica, and Moringa oleifera have
been shown to possess some antiviral characteristics. This study applies molecular docking …

In silico analysis of phytochemicals as potential inhibitors of proteases involved in SARS-CoV-2 infection

P Umadevi, S Manivannan, AM Fayad… - Journal of Biomolecular …, 2022 - Taylor & Francis
… appropriate ligands and potential inhibitors against SARS-CoV-2.Studies have indicated …
SARS CoV-2. The screening of clinically approved drugs with the druggable target SARS-CoV-…

[HTML][HTML] High affinity of host human microRNAs to SARS-CoV-2 genome: An in silico analysis

S Jafarinejad-Farsangi, MM Jazi… - Non-coding RNA …, 2020 - Elsevier
… respiratory syndrome coronavirus 2 (SARS-CoV-2) … SARS-CoV-2 genome and top miRNAs
targeting differentially expressed genes (DEGs) in lungs of patients infected with SARS-CoV-…

[PDF][PDF] In-silico analysis of protein receptors contributing to SARS-COV-2 high infectivity

I Atia, ML Salem, A Elkholy… - Information …, 2021 - digitalcommons.aaru.edu.jo
SARS-CoV and SARS-CoV-2. More precisely, The binding of the spike S1 protein of SARS-CoV
and SARSCoV-… The receptor ACE2 in the SARS-CoV-2 causes the infection of the type II …

A systematic review of experimental evidence for antiviral effects of ivermectin and an in silico analysis of ivermectin's possible mode of action against SARSCoV‐2

RT Kinobe, L Owens - Fundamental & clinical pharmacology, 2021 - Wiley Online Library
… including SARSCoV‐2 regarding efficacy, mechanisms and selective toxicity. The SARSCoV‐…
nuclear location signals for ivermectin and meta‐analyses for in vivo studies included all …

Quantitative in silico analysis of SARS-CoV-2 S-RBD omicron mutant transmissibility

T Hanai - Talanta, 2022 - Elsevier
… applied for quantitative in silico analysis of SARS-CoV-2 S… analyzed based on the complex
structure of SARS-CoV-2 mutants and ACE-2. The downloaded stereo structure of SARS-CoV

… genome analysis of novel coronavirus (SARS-CoV-2) from different geographical locations and the effect of mutations on major target proteins: An in silico insight

MI Khan, ZA Khan, MH Baig, I Ahmad, AEA Farouk… - PLoS …, 2020 - journals.plos.org
… a very systematic mutational analysis of SARS-CoV-2 genomes … analyzed 13 complete
sequences of SARS-CoV-2 reported from 13 different countries and compared with SARS-CoV