In Silico and in Vitro-Guided Identification of Inhibitors of Alkylquinolone-Dependent Quorum Sensing in Pseudomonas aeruginosa

…, B Insuasty, R Abonia, J Quiroga, S Heeb, P Williams… - Molecules, 2018 - mdpi.com
… in silico docking analysis, coupled with screening using a P. aeruginosa mCTX::P pqsA -lux …
In this study, we employed an in silico virtual screening method to search for novel PqsR …

In silico identification of lead compounds for Pseudomonas aeruginosa PqsA enzyme: Computational study to block biofilm formation

M Shahab, M Danial, T Khan, C Liang, X Duan… - Biomedicines, 2023 - mdpi.com
Pseudomonas aeruginosa is an opportunistic Gram-negative bacterium implicated in acute
and chronic nosocomial infections and a leading cause of patient mortality. Pseudomonas

In silico Identification of Putative Drug Targets in Pseudomonas aeruginosa Through Metabolic Pathway Analysis

D Perumal, CS Lim, MK Sakharkar - … , PRIB 2007, Singapore, October 1-2 …, 2007 - Springer
… analysis identified bacterial genes that are nonhomologous to human and thus making
them attractive targets for new frontline antibiotics. Our in silico approach enabled us to identify

Identification of Natural Compound Inhibitors for Multidrug Efflux Pumps of Escherichia coli and Pseudomonas aeruginosa Using In Silico High-Throughput Virtual Screening …

V Aparna, K Dineshkumar, N Mohanalakshmi… - PloS one, 2014 - journals.plos.org
Pseudomonas aeruginosa and Escherichia coli are resistant to wide range of antibiotics
rendering the treatment of infections very difficult. A main mechanism attributed to the resistance …

[PDF][PDF] In silico assessment of the genotypic distribution of virulence and antibiotic resistance genes in Pseudomonas aeruginosa

N Nahar, S Asad, T Ahmed, NI Setu… - Journal of Applied …, 2017 - japsonline.com
silico PCR amplification detected both virulence and antibiotic resistance genes of eighteen
Pseudomonas aeruginosa … usually to rapidly identify Pseudomonas aeruginosa species. …

A novel in silico antimicrobial peptide DP7 combats MDR Pseudomonas aeruginosa and related biofilm infections

Q Yin, S Wu, L Wu, Z Wang, Y Mu… - Journal of …, 2020 - academic.oup.com
… in silico, possesses broad-spectrum antimicrobial activities and immunomodulatory effects.
However, the effects of DP7 against Pseudomonas aeruginosaaeruginosa strains were used …

In Silico Identification of Natural Food Compounds as Potential Quorum-Sensing Inhibitors Targeting the LasR Receptor of Pseudomonas aeruginosa

M Magri, EM Bouricha, M Hakmi… - … and Biology Insights, 2023 - journals.sagepub.com
Pseudomonas aeruginosa is a major cause of nosocomial infections and is often associated
with biofilm-mediated antibiotic resistance. The LasR protein is a key component of the …

In silico design of polycationic antimicrobial peptides active against Pseudomonas aeruginosa and Staphylococcus aureus

O Hincapié, P Giraldo, S Orduz - Antonie Van Leeuwenhoek, 2018 - Springer
… of methodologies for discovering new AMPs to treat resistant bacteria such as Staphylococcus
aureus, Klebsiella pneumoniae, Acinetobacter baumannii and Pseudomonas aeruginosa

Inhibitors of multidrug efflux pumps of Pseudomonas aeruginosa from natural sources: An in silico high-throughput virtual screening and in vitro validation

G Mangiaterra, E Laudadio, M Cometti… - Medicinal Chemistry …, 2017 - Springer
… to identify potential lead compounds to be used as EPI in synergistic combinations with
antibiotics by an in silico … It included an in silico screening of data bases of natural compounds …

[HTML][HTML] In silico analysis and molecular modeling of RNA polymerase, sigma S (RpoS) protein in Pseudomonas aeruginosa PAO1

M Sedighi, M Moghoofei, E Kouhsari… - … of Biochemistry & …, 2015 - ncbi.nlm.nih.gov
… In this work the primary, secondary, and 3D structures of RpoS were analyzed in silico.
The primary structure determines the 3D shape known as the tertiary structure. The tertiary …