… In order to assess the contribution of variants in the noncoding, putative regulatory portions
of the genome, we selected 476 autism families from the Simons Simplex Collection (SSC) …

… autism spectrum disorder (ASD) from the Simons Simplex … all independently contributed
to the risk of autism (p < 0.05). … a role in the etiology of simplex autism. Importantly, the small …

… To do so, we use the genome-wide genotypic data from the Simons Simplex Collection (SSC)
(32), the largest cohort of autism simplex families amassed to date. Phenotypic subgroups …

… To begin to redress this, members of the Autism Genome Project Consortium (AGP) made
a proposal to Autism Speaks to collect a large number of well-phenotyped trios and to make …

… , and autistic traits. In this study, we re-analyze existing transcriptomic data from simplex
families … Finally, we compare the WGCNA-derived data on autistic traits in simplex families with …

… simplex (S-mothers, S-fathers, and S-siblings) Autism spectrum disorder families were
assessed using the Broader Phenotype Autism … and intensity of broader autism phenotype traits …

… We targeted two well-described simplex (sporadic) ASD cohorts that meet ASD criteria on
both of the current gold-standard autism diagnostic assessments (Autism Diagnostic Interview-…

… a more complete and reliable set of genomic variants for downstream analyses. Our study
focuses on the analysis of three simplex autism families consisting of one affected child, …

… In this study, we assessed whole-genome sequencing data in 2671 families with autism (discovery
cohort of 516 families, replication cohort of 2155 families). We focused on DNVs in …

Autism spectrum disorder (ASD) is a neurodevelopmental disorder (NDD) characterized by
impairments in social communication and social interaction and the presence of repetitive …