[HTML][HTML] Immunogenicity of candidate MERS-CoV DNA vaccines based on the spike protein

SS Al-Amri, AT Abbas, LA Siddiq, A Alghamdi… - Scientific reports, 2017 - nature.com
… over protein or full-length spike (S) protein-based vaccines. Here, we investigated the
immunogenicity of naked DNA vaccines expressing different fragments of MERS-CoV S protein in …

[HTML][HTML] Immunogenicity of candidate SARS-CoV-2 DNA vaccines based on the spike protein

H Lim, SE Kim, YH Lee, YH Hwang, SH Kim, MY Kim… - Virology, 2022 - Elsevier
… with the needs of vaccine, we developed four DNA vaccine candidates against SARS-CoV-2,
based on the full-length spike (S) or truncated S protein. Following mice vaccination, we …

DNA vaccines against COVID-19: Perspectives and challenges

MM Silveira, GMSG Moreira, M Mendonça - Life sciences, 2021 - Elsevier
… The bacTRL-Spike vaccine uses live, recombinant Bifidobacterium longum that contains
synthetic plasmid DNA encoding the S protein of SARS-CoV-2. Bifidobacterium is a …

A synthetic consensus anti–spike protein DNA vaccine induces protective immunity against Middle East respiratory syndrome coronavirus in nonhuman primates

K Muthumani, D Falzarano, EL Reuschel… - Science translational …, 2015 - science.org
… the lack of approved antiviral therapies or vaccines to treat or prevent this infection are …
DNA vaccine against MERS-CoV. An optimized DNA vaccine encoding the MERS spike protein

A novel concept for treatment and vaccination against Covid‐19 with an inhaled chitosan‐coated DNA vaccine encoding a secreted spike protein portion

D Tatlow, C Tatlow, S Tatlow… - Clinical and Experimental …, 2020 - Wiley Online Library
… In this paper the primary use of an inhaled plasmid DNA vaccine containing the coronavirus
spike protein DNA sequence is for treatment. The small chitosan plasmid DNA size of …

A Review on DNA Vaccines in Pre-Clinical Trials Against SARS-CoV-2

DKL Narayanan, S Djearamane, S Fuloria… - 2022 - ir.unikl.edu.my
… Traditional inactivated vaccines, mRNA vaccines (protein subunits such as spike … the DNA
vaccines for Covid - 19. This article tried to explore the available information on DNA vaccines

[HTML][HTML] Cellular and humoral immunogenicity of a candidate DNA vaccine expressing SARS-CoV-2 spike subunit 1

KA Alluhaybi, RH Alharbi, RY Alhabbab, ND Aljehani… - Vaccines, 2021 - mdpi.com
… 1 (S1) of the spike protein represents an attractive immunogen for vaccine development.
Here, we developed and assessed the immunogenicity of a DNA vaccine encoding the SARS-…

[HTML][HTML] Synergistic immunity and protection in mice by co-immunization with DNA vaccines encoding the spike protein and other structural proteins of SARS-CoV-2

J Chen, B Huang, Y Deng, W Wang, C Zhai, D Han… - Vaccines, 2023 - mdpi.com
… In this study, co-immunization with two DNA vaccines expressing the S and N proteins induced
high … DNA vaccines expressing the S protein induced increased S protein-specific cellular …

A brief review on DNA vaccines in the era of COVID-19

M Shafaati, M Saidijam, M Soleimani, F Hazrati… - Future …, 2022 - Taylor & Francis
… This article provides a brief overview of DNA vaccines. First, the basic DNA vaccine design
… The spike (S) protein of SARS-CoV-2 is the main antigen used in preclinical and clinical …

[HTML][HTML] Immunogenicity of a DNA vaccine candidate for COVID-19

TRF Smith, A Patel, S Ramos, D Elwood, X Zhu… - Nature …, 2020 - nature.com
… engineered a synthetic DNA vaccine targeting the MERS coronavirus Spike (S) protein, the
major … Here we build on this prior experience to generate a synthetic DNA-based vaccine