… Our results indicated that SARS-CoV-2 spike protein expression induces a senescent
state in spike-transfected A549 cells that is associated with the DNA damage response and …

… of inflammatory factors known as senescence-associated secretory … We also show that the
expression of the senescence marker … The sustained infection-induced paracrine senescence …

… -CoV-2 spike (S) protein-based vaccination, could prevent or mitigate severe COVID-19. …
senescence in virus-susceptible cells by SARS-CoV-2 infection, the paracrine senescence …

… -2 Spike pseudotyped VSV can cause non-senescent cells to … and protein was higher in
senescent than non-senescent … either senescent preadipocytes or non-senescent preadipocytes, …

… senescence. In this study, we investigate the role of the SARS-COV-2 spike protein (S-protein)
in regulating the senescence … or overexpression of S-protein in ARPE-19 decreased cell …

… Spike gene transfection of A549 cells … -2 Spike protein induces a senescent state in infected
or Spike transfected A549 cells, potentially leading to enhanced SASP associated paracrine …

… These pseudotypes all induced senescence in the cells in a spike-protein-… senescent upper
airway epithelial cells may attract and activate macrophages through paracrine senescence …

… We also focused on integrin genes since the Spike protein contains an arginine-glycine-aspartic
acid motif in the RBD site that is recognized by some integrins as a potential receptor of …

… -2 spike protein (S) interacts with cell surface receptors for viral entry to infect human cells.
The S protein of … To test further the paracrine effects of the cytokine-induced SASP on ACE2 …

… It is important to acknowledge that this observation is limited to only one case, and we did
not perform co-staining for viral proteins and senescence markers. Nevertheless, the presence …