… -binding domain of MERS-CoV spike protein induces much stronger local mucosal immune responses than subcutaneous immunization: Implication for designing …

C Ma, Y Li, L Wang, G Zhao, X Tao, CTK Tseng, Y Zhou… - Vaccine, 2014 - Elsevier
… that subcutaneous (sc) vaccination of a recombinant protein … intranasal (in) and sc immunization
pathways. We found that in … of developing MERS-CoV RBD protein into an effective and …

A single subcutaneous or intranasal immunization with adenovirus‐based SARS‐CoV‐2 vaccine induces robust humoral and cellular immune responses in mice

E Kim, FJ Weisel, SC Balmert, MS Khan… - European journal of …, 2021 - Wiley Online Library
… -CoV-2 spike protein and are administered intramuscularly, whereas our vaccine encodes
the gene for SARS-CoV-2-S1 subunit and is being tested for its immunogenicity via IN and SC …

Immunogenicity and protection efficacy of monomeric and trimeric recombinant SARS coronavirus spike protein subunit vaccine candidates

J Li, L Ulitzky, E Silberstein, DR Taylor, R Viscidi - Viral immunology, 2013 - liebertpub.com
immunized with recombinant spike proteins adjuvanted with TiterMax. Mice (n=5) were
immunized with PBS or recombinant proteins … mice were immunized three times subcutaneously (…

Immunological Response to Subcutaneous and Intranasal Administration of SARS-CoV-2 Spike Protein in Mice

M Kinoshita, K Muranishi, K Kawaguchi, K Sudo… - Vaccines, 2024 - mdpi.com
immunizations, mice … immunized with either S1 + alum. This was followed by booster doses
of S1 + CpG on days 14 and 28. After the completion of the three scheduled immunizations, …

Immunogenicity of a receptor-binding domain of SARS coronavirus spike protein in mice: implications for a subunit vaccine

AN Zakhartchouk, C Sharon, M Satkunarajah… - Vaccine, 2007 - Elsevier
… Four groups of five mice were immunized subcutaneously twice at a 4-week interval, with …
compared to the splenocytes of mice immunized with spike protein formulated with alum. The S …

[HTML][HTML] Oral subunit SARS-CoV-2 vaccine induces systemic neutralizing IgG, IgA and cellular immune responses and can boost neutralizing antibody responses …

J Pitcovski, N Gruzdev, A Abzach, C Katz, R Ben-Adiva… - Vaccine, 2022 - Elsevier
… the viral spike (S) protein, a surface protein that undergoes … viral S protein, two domains of
the viral nucleocapsid protein (N), … had been subcutaneously immunized with viral S1 protein, …

Adenoviral expression of a truncated S1 subunit of SARS-CoV spike protein results in specific humoral immune responses against SARS-CoV in rats

RY Liu, LZ Wu, BJ Huang, JL Huang, YL Zhang, ML Ke… - Virus research, 2005 - Elsevier
… Rats were immunized either subcutaneously or intranasally with Ad-S … immunized animals
generated humoral immunity against the SARS-CoV spike protein, and the sera of immunized

Protective immunity against SARS subunit vaccine candidates based on spike protein: lessons for coronavirus vaccine development

A Khalaj-Hedayati - Journal of immunology research, 2020 - Wiley Online Library
… Mucosal immunization offers several advantages over other … only IN immunization of mice
by truncated S-protein with protollin … The fact that IM immunization developed a high level of …

Superior immune responses induced by intranasal immunization with recombinant adenovirus-based vaccine expressing full-length Spike protein of Middle East …

MH Kim, HJ Kim, J Chang - PLoS One, 2019 - journals.plos.org
… and full-length Spike protein (rAd/Spike). We found that immunization with candidate vaccines
via … and neutralizing antibodies against MERS spike pseudotyped virus. Especially, rAd/…

[HTML][HTML] Adjuvanted SARS-CoV-2 spike protein elicits neutralizing antibodies and CD4 T cell responses after a single immunization in mice

K Wørzner, DJ Sheward, ST Schmidt, L Hanke… - …, 2021 - thelancet.com
… To compare different adjuvant systems for stimulating immune responses to a single
dose of SARS-CoV-2 spike trimer protein, we immunized mice subcutaneously with …